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Keywords: TGF-β
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Journal Articles
Journal: Development
Development (2020) 147 (18): dev189373.
Published: 23 September 2020
...Alexis R. Lanza; Elaine C. Seaver ABSTRACT The TGF-β superfamily comprises two distinct branches: the Activin/Nodal and BMP pathways. During development, signaling by this superfamily regulates a variety of embryological processes, and it has a conserved role in patterning the dorsal-ventral body...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2077–2088.
Published: 15 June 2016
... with transgene-encoded or chemical inhibitors reveals that re-epithelializing keratinocytes repopulate wounds by TGF-β- and integrin-dependent lamellipodial crawling at the leading edges of the epidermal tongue. In addition, re-epithelialization requires long-range epithelial rearrangements, involving radial...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 943–952.
Published: 1 March 2015
... for this process remains incomplete. Here, we show that TGF-β-receptor signaling is required during gastrulation to pattern the anterior skeleton. To block TGF-β signaling, we used SB431542 (SB43), a specific inhibitor of the TGF-β type I receptor Alk4/5/7. Treatment with SB43 during gastrulation blocks anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3683–3696.
Published: 1 October 2014
.... Bioinformatics analysis of the tendon transcriptome showed that the two most strongly modified signalling pathways were TGF-β and MAPK. TGF-β/SMAD2/3 gain- and loss-of-function experiments in mouse limb explants and mesenchymal stem cells showed that TGF-β signalling was sufficient and required via SMAD2/3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3147–3156.
Published: 1 September 2012
...Nadine S. Jahchan; Douglas Wang; Mina J. Bissell; Kunxin Luo Mammary epithelial cells undergo structural and functional differentiation at late pregnancy and parturition to produce and secrete milk. Both TGF-β and prolactin pathways are crucial regulators of this process. However, how...
Journal Articles
Journal: Development
Development (2009) 136 (16): 2803–2813.
Published: 15 August 2009
..., is still poorly understood. In Xenopus , members of the TGF-β family such as the nodal-related proteins and activin act as morphogens to induce mesoderm and endoderm. In an effort to understand the mechanisms and dynamics of morphogen gradient formation, we have used fluorescently labelled activin to study...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (10): 1813–1822.
Published: 15 May 2008
...Patrick Herr; Ganna Korniychuk; Yukiyo Yamamoto; Kristina Grubisic; Michael Oelgeschläger The TGF-β superfamily of secreted signalling molecules plays a pivotal role in the regulation of early embryogenesis, organogenesis and adult tissue homeostasis. Here we report the identification of Xenopus N...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3929–3939.
Published: 1 November 2007
...Kevin Roarty; Rosa Serra Transforming growth factor-β (TGF-β) plays an essential role in growth and patterning of the mammary gland, and alterations in its signaling have been shown to illicit biphasic effects on tumor progression and metastasis. We demonstrate in mice that TGF-β (Tgfβ) regulates...
Journal Articles
Journal: Development
Development (2007) 134 (20): 3723–3732.
Published: 15 October 2007
...Vesna Todorovic; David Frendewey; David E. Gutstein; Yan Chen; Laina Freyer; Erin Finnegan; Fangyu Liu; Andrew Murphy; David Valenzuela; George Yancopoulos; Daniel B. Rifkin Latent TGF-β binding protein 1 (LTBP1) is a member of the LTBP/fibrillin family of extracellular proteins. Due to the usage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4981–4991.
Published: 15 December 2006
...Louise Parker; Jeremy E. Ellis; Minh Q. Nguyen; Kavita Arora Axon guidance is regulated by intrinsic factors and extrinsic cues provided by other neurons, glia and target muscles. Dawdle (Daw), a divergent TGF-β superfamily ligand expressed in glia and mesoderm, is required for embryonic motoneuron...
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
... cycle quiescence in the germline stem cell population, in addition to prolonging lifespan. The inactivation of either protein causes aberrant germline proliferation during diapause-like `dauer' development, whereas the loss of AMPK uncouples developmental arrest from lifespan extension. Reduced TGF-β...
Journal Articles
Journal: Development
Development (2005) 132 (15): 3505–3513.
Published: 1 August 2005
...Jianjun Wang; William A. Mohler; Cathy Savage-Dunn TGF-β signaling in the nematode Caenorhabditis elegans plays multiple roles in the development of the animal. The Sma/Mab pathway controls body size, male tail sensory ray identity and spicule formation. Three Smad genes, sma-2 , sma-3 and sma-4...
Journal Articles
Journal: Development
Development (2004) 131 (24): 6163–6174.
Published: 15 December 2004
... differentiation factor 11(GDF11), a member of the TGF-β ligand family, governs the number and maturation of islet progenitor cells in mouse pancreas development. Gdf11 is expressed in embryonic pancreatic epithelium during formation of islet progenitor cells that express neurogenin 3. Mice deficient for Gdf11...
Journal Articles
Journal: Development
Development (2002) 129 (1): 221–231.
Published: 1 January 2002
... enhances the extended life span of certain daf-2 mutants ( Larsen et al., 1995 ; Gems et al., 1998 ). Signals from the reproductive system require DAF-2, DAF-16 and DAF-12 activity to modulate C. elegans life span ( Hsin and Kenyon, 1999 ). DAF-7 (TGF-β), DAF-2 (insulin) and DAF-11 (cGMP) signaling...
Journal Articles
Journal: Development
Development (2001) 128 (11): 1933–1942.
Published: 1 June 2001
...Nicole Dünker; Norbert Schuster; Kerstin Krieglstein Programmed cell death (PCD) is a key phenomenon in the regulation of cell number in multicellular organisms. We have shown that reduction of endogenous transforming growth factor β (TGF-β) prevents apoptotic PCD of neurons in the developing...
Journal Articles
Journal: Development
Development (1994) 1994 (Supplement): 53–60.
Published: 1 January 1994
... molecules belong to large families of highly conserved proteins, originally identified as mammalian growth factors. The largest known family is related to Transforming Growth Factor-β (TGF-β) and currently consists of at least 24 different members. Genetic studies in Drosophila on the TGF-β related gene...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 31–36.
Published: 1 April 1989
...). The maternal mRNA anuran oocytes in serum-supplemented medium. Reprod. Nutr. Vgl is correctly localized following injection into Xenopus Develop. 20, 699-708. oocytes. Nature, Lond. 336, 592-595. Vgl TGF-β RNA localization polarity microtubules microfilaments Xenopus Copyright © 1989...
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 65–74.
Published: 1 April 1989
...William M. Gelbart The type β transforming growth factor (TGF-β) family of secreted factors encompasses a wide range of structurally related proteins that control the state of determination or differentiation in a wide variety of cell types. For all members of the family that have been studied...
Journal Articles
Journal: Development
Development (1989) 105 (4): 665–677.
Published: 1 April 1989
.... theor. Biol. 62 , 479 – 490 MASSAGUE J. ( 1987 ). The TGF-β family of growth and differentiation factors. Cell 49 , 437 – 438 MEINHARDT H. ( 1982 ). Models of Biological Pattern Formation. London : Academic Press . MELTON D. A. ( 1987 ). Translocation...