... activation, the toxicity of chimeric toxins composed of HB-EGF or TGF-α coupled to Pseudomonas exotoxin (PE) were used as measures of receptor expression. TGF-α or HB-EGF binds to EGF-receptor (ErbB1), while HB-EGF, in addition, binds to ErbB4. The results indicate that ErbB1 is inefficient in mediating TGF...

...Choy May Chia; Robert M. L. Winston; Alan H. Handyside ABSTRACT Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α) through their common receptor, epidermal growth factor receptor (EGFR) are known to enhance mitogenesis, development and implantation in several species...

...Pätvi J. Miettine; Kristiina Heikinheimo Transforming growth factor-alpha (TGF- α ) mRNA is expressed in several pancreatic cancer cell lines, but its expression during normal fetal pancreas development has not been studied. We investigated the expression of TGF- α , its receptor (EGF-R...

... of either TGF- α or EGF to stimulate the rate of blastocoel expansion in the mouse. Picomolar concentrations of either TGF- α or EGF stimulate the rate of blastocoel expansion in a concentration-dependent manner, and the continual presence of the growth factor is required to observe the stimulatory effect...