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Keywords: TGFβ
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev188490.
Published: 12 March 2021
...Shunji Jia; Anming Meng ABSTRACT The transforming growth factor β (TGFβ) signaling family is evolutionarily conserved in metazoans. The signal transduction mechanisms of TGFβ family members have been expansively investigated and are well understood. During development and homeostasis, numerous TGFβ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev195495.
Published: 08 February 2021
...Émilie Lamarche; Hamood AlSudais; Rashida Rajgara; Dechen Fu; Saadeddine Omaiche; Nadine Wiper-Bergeron ABSTRACT SMAD2 is a transcription factor, the activity of which is regulated by members of the transforming growth factor β (TGFβ) superfamily. Although activation of SMAD2 and SMAD3 downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193219.
Published: 18 January 2021
... inhibiting the chemokine receptor gene cxcr3.1 through a mechanism involving Tgfβ/pSmad3 signaling. Thus, Ccn2a positively modulates the innate regenerative response of the adult zebrafish heart. * Present address: Institute of Cardiovascular Regeneration, Goethe University, Frankfurt 60590, Germany...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev194027.
Published: 15 January 2021
... C2C12 myoblasts and injured skeletal muscle revealed a significant dysregulation of EMT-related genes, and identified TGFβ as a key upstream regulator. Importantly, inhibition of TGFβR1 and its downstream effectors, and the EMT transcription factor Snai2, restored many aspects of myogenic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev185827.
Published: 23 December 2020
... development Follistatin Pattern formation Pax6 Self-organisation TGFβ Positional cues that govern cell fate decisions in the embryo may arise at multiple organisational levels: cell intrinsically (e.g. asymmetric cell divisions), tissue intrinsically (e.g. reaction-diffusion mechanisms), tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev190942.
Published: 28 September 2020
...-1/ Summary:   cyp19a1a- mediated suppression of dmrt1 establishes a bipotential gonad and female fate acquisition, possibly through rbpms2 , which is required for female fates, even in the absence of Dmrt1. Rbpms Sex-determination Bipotential Cyp19a1a Dmrt1 TGFβ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... under the regulation of TGFβ and independently of mechanical stimuli from muscles. Whereas BMP2 regulates the growth of all examined sesamoids, the differentiation of lateral fabella or digit sesamoids is regulated redundantly by BMP4 and BMP2. Next, we show that whereas patella and digit sesamoids...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev159947.
Published: 09 July 2018
..., smoothened and GLI3 in cortical stromal cells that control nephron formation via TGFβ signaling. GLI Hedgehog Stroma Nephron Mouse Crosstalk TGFβ The mammalian kidney contains hundreds of thousands of nephrons that each connect to a collecting system composed of collecting ducts, calyces...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4476–4480.
Published: 15 December 2017
...Jan L. Christian; Carl-Henrik Heldin The 10th FASEB meeting ‘The TGFβ Superfamily: Signaling in Development and Disease' took place in Lisbon, Portugal, in July 2017. As we review here, the findings presented at the meeting highlighted the important contributions of TGFβ family signaling to normal...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3336–3348.
Published: 15 September 2017
... factor beta (TGFβ) signalling is essential for VBW closure, but the responding cells are not known. Here, we identify in mouse a population of migratory myofibroblasts at the leading edge of the closing VBW that express the actin-binding protein transgelin (TAGLN) and TGFβ receptor (TGFβR). These cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2270–2281.
Published: 15 June 2017
...Maria Dolores Molina; Magali Quirin; Emmanuel Haillot; Felipe Jimenez; Aline Chessel; Thierry Lepage Dorsal-ventral axis formation in the sea urchin embryo relies on the asymmetrical expression of the TGFβ Nodal. The p38-MAPK pathway has been proposed to be essential for dorsal-ventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1498–1509.
Published: 15 April 2017
...-type keratinocytes into nipple-like epidermis. To identify candidate nipple-specific signaling factors, we compared gene expression signatures of sorted Pdgfrα-positive ventral K14-PTHrP and wild-type fibroblasts, identifying differentially expressed transcripts that are involved in WNT, HGF, TGFβ, IGF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (1): 106–114.
Published: 01 January 2017
..., senescence depends on TGFβ but is independent of ERK/MAPK activation. Furthermore, elimination of senescent cells through temporary TGFβ inhibition leads to developmental defects. Our findings uncover conserved and new roles of senescence in vertebrate organogenesis and support the view that cellular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... superficially embedded within the quadriceps tendon. At the cellular level, we show that, similar to bone eminences, the patella is formed secondarily by a distinct pool of Sox9 - and Scx -positive progenitor cells. Finally, we show that TGFβ signaling is necessary for the specification of patella progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1639–1650.
Published: 01 May 2015
... the lumen in the transverse plane, allowing sufficient time for lumen growth via an osmotic process along the longitudinal dimension. The dynamics of lumen formation is controlled by the TGFβ pathway and ROCK activity. Our findings reveal a TGFβ-ROCK-actomyosin contractility axis that coordinates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4537–4547.
Published: 01 December 2014
...William T. Chiu; Rebekah Charney Le; Ira L. Blitz; Margaret B. Fish; Yi Li; Jacob Biesinger; Xiaohui Xie; Ken W. Y. Cho Nodal/TGFβ signaling regulates diverse biological responses. By combining RNA-seq on Foxh1 and Nodal signaling loss-of-function embryos with ChIP-seq of Foxh1 and Smad2/3, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4489–4499.
Published: 01 December 2014
... that integrin αVβ8 activates angiosuppressive TGFβ gradients in the brain, which inhibit endothelial cell sprouting. Loss of αVβ8 in the brain or downstream TGFβ1-TGFBR2-ALK5-Smad3 signaling in endothelial cells increases vascular sprouting, branching and proliferation, leading to vascular dysplasia...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 909–917.
Published: 15 February 2014
... of clefting of the soft palate remains unclear because few animal models exhibit an isolated cleft in the soft palate. Using three-dimensional microCT images and histological reconstruction, we found that loss of TGFβ signaling in the palatal epithelium led to soft palate muscle defects in Tgfbr2 fl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (3): 538–547.
Published: 01 February 2014
... declare no competing financial interests. 26 5 2013 14 11 2013 © 2014. Published by The Company of Biologists Ltd 2014 Prox1 Liver Hepatic precursors TGFβ Mouse Dlk1 + hepatoblasts were isolated from E12.5 wild-type mouse livers via fluorescence-activated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4177–4181.
Published: 15 October 2013
... Growth Factor β (TGFβ) family influence all three germ layers; the ligands are required to induce endoderm and mesoderm, whereas inhibitors are required for formation of the ectoderm. Here, we demonstrate a vital role for maternal Coco, a secreted antagonist of TGFβ signalling, in this process. We show...
Includes: Supplementary data