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Keywords: TCF/LEF
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (9): 1687–1697.
Published: 1 May 2017
... . Functional and epistatic studies showed that GPX4 functions at the Tcf/Lef level, independently of selenocysteine activation. Mechanistically, GPX4 interacts with Tcf/Lefs and inhibits Wnt activity by preventing the binding of Tcf/Lefs to the promoters of Wnt target genes, resulting in inhibitory action...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2206–2216.
Published: 15 June 2016
..., namely the NC and the forebrain. Our analysis of AP2α-Cre;Tcf7l1 fl/fl mutants identified Tcf7l1 as a negative regulator of the NC population. Given that the NC is positively regulated by the Wnt/β-catenin pathway in all vertebrates studied, other Tcf/Lefs should be responsible for activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (21): 4341–4353.
Published: 1 November 2006
.... 2006 NLK Delta TCF/Lef ERK MAP kinase TAK1 Germ layers Mesoderm Endoderm Sea urchin embryo The mesoderm of the sea urchin embryo originates from two populations of precursors, the primary mesenchyme cells (PMCs) and the secondary mesenchyme cells (SMCs), which are both generated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (20): 4907–4917.
Published: 15 October 2003
... in its intronic sequence and that these multiple FREs comprise Ets-binding and Tcf/Lef-binding motifs that lie in juxtaposition. Functional and physical analyses indicate that signaling pathways of Fgf, Bmp and Wnt are integrated on these FREs to regulate the expression of Xcad3 in the posterior neural...
Journal Articles
Journal: Development
Development (1999) 126 (10): 2285–2298.
Published: 15 May 1999
...-cycle kinetics, overt terminal differentiation or intercellular adhesion, and correlated with stimulation or inhibition of transactivation of a TCF/LEF reporter in basal keratinocytes. We conclude that the elevated level of cytoplasmic β-catenin in those keratinocytes with characteristics of epidermal...