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Keywords: TALENs
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Journal Articles
Journal: Development
Development (2016) 143 (15): 2868–2875.
Published: 1 August 2016
... be transferable to other species. CRISPR/Cas9 TALENs Knockouts Primordial germ cells Genome editing Xenopus In summary, leapfrogging mitigates founder lethality when targeting essential genes and a high percentage of homozygous mutant F1 animals can be generated for subsequent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 481–487.
Published: 15 January 2014
...-like effector nucleases (TALENs) are starting to fulfill this potential with the advantages of low cost and fast construction times. Here, we report that TALENs are highly effective at inducing mutations in specific genomic loci in the ascidian chordate Ciona intestinalis. In Ciona there are well...
Includes: Supplementary data