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Keywords: TALEN
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Journal Articles
Journal: Development
Development (2017) 144 (5): 928–934.
Published: 1 March 2017
...Lorna Taylor; Daniel F. Carlson; Sunil Nandi; Adrian Sherman; Scott C. Fahrenkrug; Michael J. McGrew In this work we use TALE nucleases (TALENs) to target a reporter construct to the DDX4 ( vasa ) locus in chicken primordial germ cells (PGCs). Vasa is a key germ cell determinant in many animal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4713–4722.
Published: 15 December 2016
... understanding of titinopathy and its related therapies. Zebrafish were handled following the guidelines of the Mayo Clinic Institutional Animal Care and Use Committee (IACUC protocol A17814). The WIK line was used. TALEN pairs in ttn.2 and ttn.1 ( Seeley et al., 2007 ) were designed using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3785–3795.
Published: 15 October 2016
... by The Company of Biologists Ltd 2016 Summary: Genome-editing approaches in zebrafish reveal that distinct signaling pathways downstream of Flt4 govern lymphatic morphogenesis and differentiation in different anatomical locations. Flt4 TALEN Vegfc Lymphatic Zebrafish The lymphatic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2842–2852.
Published: 1 August 2016
... generated zebrafish mutants lacking all four zebrafish Mesp genes by using TALEN-mediated genome editing. Contrary to the situation in the mouse Mesp2 mutant, in the zebrafish Mesp quadruple mutant embryos the positions of somite boundaries were clearly determined and morphological boundaries were formed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (19): 3807–3818.
Published: 1 October 2014
... in vivo , but it also paves the way for other sophisticated genetic manipulations of the zebrafish genome. 14 1 2014 30 7 2014 © 2014. Published by The Company of Biologists Ltd 2014 TALEN Genome engineering Homologous recombination Knock-in sox2 gfap Custom...
Includes: Supplementary data