... expression patterns; functions were investigated on the basis of the severe, usually embryonic lethal, phenotypes caused by ablation of the genes. In addition, most T-box gene mutations, like those in T , show dose sensitivity, thereby giving rise to dose-dependent effects in heterozygotes. These early...

... specification, have not been well defined. Our present study identifies the Dorsocross T-box genes as key mediators of combined Dpp and Wg signals during this process. The Dorsocross genes are induced within the segmental areas of the dorsal mesoderm that receive intersecting Dpp and Wg inputs. Dorsocross...

.... 2004 Bmp Wnt Posterior mesoderm T-box genes Zebrafish The posterior body of the zebrafish embryo is formed by a network of intercellular signaling molecules that pattern the formation of the ventrolateral mesoderm, which ultimately gives rise to the posterior (trunk and tail) mesoderm...

...Roger Pocock; Julie Ahringer; Michael Mitsch; Sara Maxwell; Alison Woollard T-box genes form a large family of conserved transcription factors with diverse roles in animal development, but so far functions for only a few have been studied in detail. Here we show that four Caenorhabditis elegans T...

... for correspondence (e-mail: mlogan@nimr.mrc.ac.uk ) 10 3 2003 © 2003. 2003 Limb development Limb-type identity Tbx5 T-box genes Mouse Chick The forelimb and hindlimb buds are derived from territories of the lateral plate mesoderm located at defined rostrocaudal levels along...

...@rascal.med.harvard.edu ) 09 17 1998 15 09 1998 © 1998 by Company of Biologists 1998 Limb development T-box genes Chick Limb identity Ptx Tbx Candidates for endogenous FGFs involved in limb bud initiation include FGF8 , which is transiently expressed in the intermediate...

... 22 04 1998 © 1998 by Company of Biologists 1998 Gastrulation Tail organizer Neural induction Neural regionalization Gnot1 Brachyury T-box genes Chick embryo During gastrulation, a uniform population of embryonic cells segregates to form definitive germ layers...

...-u.ac.jp ) 21 10 1997 08 12 1997 © 1998 by Company of Biologists 1998 Fibroblast growth factor FGF Limb identity T-box genes Tbx4 Tbx5 Chick Additional limb In vertebrates, two pairs of limb buds are formed from the lateral plate mesoderm at specific...