... that a conditional knockout of Yy1 in the hematopoietic system results in an early T cell developmental blockage at the double negative (DN) 1 stage with reduced Notch1 signaling. There is a lineage-specific requirement for YY1 PcG function. YY1 PcG domain is required for T and B cell development but not necessary...

... Ebihara , T. , Seo , W. and Taniuchi , I. ( 2017 ). Roles of RUNX complexes in immune cell development . Adv. Exp. Med. Biol.   962 , 395 - 413 . 10.1007/978-981-10-3233-2_24 Egawa , T. and Littman , D. R. ( 2008 ). ThPOK acts late in specification of the helper T cell...

...Julie Gordon; Nancy R. Manley The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade...

..., including hypomethylation of repetitive sequences, low body weight, distinct cranial facial anomalies and T cell death by apoptosis. These results indicate that Dnmt3b plays an essential role at different stages of mouse development, and that ICF missense mutations cause partial loss of function...