... and validated against experiments from the literature. A predicted YAP-cMyc axis is validated in data from cells and mice. Systems biology Cardiomyocyte proliferation Regeneration National Institutes of Health R01HL162925 R01HL160665 National Science Foundation http://dx.doi.org...

... identity Dynamical systems Enhancer selection Statistical physics Systems biology Summary: EnhancerNet, a model for cell identity based on TF-enhancer interactions, explains diverse phenomena and makes specific predictions on large-scale cell identity processes, including differentiation...

... characterization Structure-function Systems biology Summary: This Meeting Review summarises the key advances presented at The Notch IX meeting, which was held in Athens, Greece, in October 2015. © 2016. Published by The Company of Biologists Ltd 2016 Competing interests The authors declare...

... mechanism in any tissue and future investigations will explore the presence of analogous examples in other biological systems. © 2014. Published by The Company of Biologists Ltd 2014 Segmentation clock Oscillation Traveling wave Systems biology Computational modeling Gene expression...

... oscillator Systems biology The temporal coordination of gene function is essential for the precise control of cellular activity and function in living organs. Cell cycle and circadian oscillators are well-conserved molecular machineries that are found in many species. Such biological clocks generate...

... 11 4 2014 © 2014. Published by The Company of Biologists Ltd 2014 Sensory development Hair cells Atoh1 Mathematical modeling Systems biology Signal competition Notch signaling plays a dual role during the sensory development of the inner ear, where it is required during...

... to morpholino toxicity. Thus, of 12 test genes that were both computationally predicted and subsequently identified through the S score as having a cardiac phenotype, 11 were further validated to have underlying alterations in atrial function, valvular function, CO or cardiac conduction. Systems...

... at the growing posterior end of the embryo, they are grouped together and organized into segments known as somites that will later differentiate into the vertebral column and trunk, and limb muscle tissues ( Pourquié, 2011 ). Segmentation clock Oscillation Protein half-life Systems biology...

[email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. © 2012. Morphogenesis Pattern formation Quantitative analysis Systems biology Cellular computation Over the last 30 years, advances in genetics...

... acid Sonic hedgehog Mathematical modelling Mouse limb development Systems biology Digoxigenin-labelled antisense riboprobes were used for whole-mount RNA in situ hybridization ( Panman et al., 2006 ). Minimally three, but often many more, independent embryos were analysed and yielded...

... declare no competing financial interests. 10 5 2010 © 2010. 2010 Hox genes In silico evolution Mutual entropy Systems biology Numerical simulations of evolution have a long history in ecology and molecular evolution but are less used in cell and developmental biology...