..., and synergistically activate pulmonary epithelial- and cardiac-gene promoters. However, the relevance of this synergy has not been demonstrated in vivo. We show that Gata6-Titf1 ( Gata6-Nkx2.1 ) double heterozygous( G6-Nkx DH) embryos and mice have severe defects in pulmonary epithelial differentiation and distal...

... Nuclear receptors Embryo cultures Endoderm Branchial arches Pharyngeal pouches Mouse Synergy Agonists Antagonists Teratogenicity Retinoic acids (RAs), the active metabolites of vitamin A, exert their pleiotropic effects through binding to two families of nuclear receptors, the retinoic...