..., and synergistically activate pulmonary epithelial- and cardiac-gene promoters. However, the relevance of this synergy has not been demonstrated in vivo. We show that Gata6-Titf1 ( Gata6-Nkx2.1 ) double heterozygous( G6-Nkx DH) embryos and mice have severe defects in pulmonary epithelial differentiation and distal...

... is specified by mesoderm. Development 110 , 589 -607. Gavalas, A., Trainor, P., Ariza-McNaughton, L. and Krumlauf,R. ( 2001 ). Synergy between Hoxa1 and Hoxb1 :the relationship between arch patterning and the generation of cranial neural crest. Development 128 , 3017 -3027. Gehin, M., Vivat...

... ) * Present address: Center for Molecular Genetics, Department of Biology, University of California at San Diego, La Jolla, CA 92093, USA 08 05 1999 10 07 2000 © 2000 by Company of Biologists 2000 dia1 cAMP-related gene Differentiation Cell cycle PS point Synergy...

... of transcriptional synergy, cooperative binding to DNA and cooperative contact of bound activators with the transcription complex. Second, we find that the synergistic activity of hb and bcd is ‘promiscuous’. For example, a maternally expressed Gal4-Sp1 fusion protein can functionally replace hb in the stripe 2...