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Helena Acosta, Dobromir Iliev, Tan Hooi Min Grahn, Nadège Gouignard, Marco Maccarana, Julia Griesbach, Svende Herzmann, Mohsen Sagha, Maria Climent, Edgar M. Pera
Development (2015) 142 (6): 1146–1158.
Published: 15 March 2015
... to and inhibits HtrA1, prevents degradation of the proteoglycan Syndecan 4 and restricts paracrine FGF/Erk signaling. Our data suggest that PN1 is a negative-feedback regulator of FGF signaling and has important roles in ectoderm and head development. Xenopus embryos and explants were prepared, cultured...
Includes: Supplementary data
Development (2009) 136 (18): 3143–3152.
Published: 15 September 2009
...Cammon B. Arrington; H. Joseph Yost One of the first steps in zebrafish heart and gut organogenesis is the migration of bilateral primordia to the midline to form cardiac and gut tubes. The mechanisms that regulate this process are poorly understood. Here we show that the proteoglycan syndecan 2...
Includes: Multimedia, Supplementary data
Development (2005) 132 (20): 4621–4633.
Published: 15 October 2005
... that the cell surface proteoglycan syndecan SDN-1 functions autonomously in neurons to control the neural migration and guidance choices of outgrowing axons. Epistasis analysis suggests that heparan sulfate (HS) attached to SDN-1 can regulate guidance signaling by the Slit/Robo pathway. Furthermore, SDN-1 acts...
Development (1993) 119 (Supplement): 205–212.
Published: 1 December 1993
... inhibitors. A major source of this cell surface heparan sulfate is a multigene family of proteoglycans, the syndecans that are expressed developmentally in association with changes in tissue organization and morphology and induced during wound repair. In this review, we describe mechanisms underlyin g...