... 2022 Summary: The combination of light-sheet fluorescence and expansion microscopy enables imaging of mature human brain organoids in toto and down to synaptic resolution. Brain organoid Expansion microscopy Light-sheet fluorescence microscopy Super-resolution Synaptogenesis...

... retardation protein binds staufen transcript to regulate the Coracle scaffold determining synaptic glutamate receptor accumulation, with intercellular signaling through Mothers against decapentaplegic phosphorylation driving synaptic bouton formation. FMRP Fragile X syndrome Synaptogenesis Synapse...

... by The Company of Biologists Ltd 2015 Summary: In the developing mouse hippocampus, intrinsic neuronal excitability does not alter CA3 neuron development but regulates spine formation and synaptic transmission in CA1 neurons. Neural activity Synaptogenesis Dendritic spines Hippocampus...

... development but were subsequently lost as the animals developed. Vertebrate zyxin regulates cytoskeletal responses to mechanical stress in culture. Our work provides in vivo evidence in support of such a role for zyxin. In particular, zyx-1 mutant synaptogenesis phenotypes were suppressed by disrupting...

... trajectories but different branching morphologies and distributions of presynaptic sites. Compared with Trpa1b neurons, Isl1SS neurons display reduced branch growth and synaptogenesis at the hindbrain-spinal cord junction. The subtype-specific morphogenesis of Isl1SS neurons depends on the guidance receptor...

... proteins in synaptic ribbon bodies. Although the importance of Ribeye for the function and physical integrity of ribbon synapses has been shown, a specific role in synaptogenesis has not been described. Here, we have modulated Ribeye expression in zebrafish hair cells and have examined the role of Ribeye...

... suppresses the synaptic overgrowth phenotypes of Abl mutants, suggesting that Abi acts cooperatively with Ena to antagonize Abl function in synaptogenesis. Intriguingly, overexpressing Abi or Ena alone in cultured cells dramatically redistributed peripheral F-actin to the cytoplasm, with aggregates...

... of contacts between myopodia and growth cones is traced by time-lapse imaging with 2-minute intervals that spans the entire period of synaptogenesis (13:17-14:45 hours). Time elapsed from the first image is shown in minutes. The fate of two contacts was traced (arrowheads). The upper one was established after...

... of the muscle during the initial stage of neuromuscular synaptogenesis. It is not clear how these pre-patterned AChR clusters are assembled, and to what extent they contribute to pre- and post-synaptic differentiation during development. Here, we show that genetic deletion of the AChR γ-subunit gene in mice...

... development. * Author for correspondence (e-mail: kendal.broadie@vanderbilt.edu ) 4 2 2008 © 2008. 2008 Fragile X Syndrome Mental retardation Autism Neural development Translation Synaptogenesis Synaptic pruning Fragile X Syndrome (FraX) is a commonly inherited mental...

... protein Dok-7 is essential for neuromuscular synaptogenesis. Science 312 , 1802 -1805. Qu, Z. C., Moritz, E. and Huganir, R. L. ( 1990 ). Regulation of tyrosine phosphorylation of the nicotinic acetylcholine receptor at the rat neuromuscular junction. Neuron 4 , 367 -378. Salpeter, M. M...

...-mail: granatom@mail.med.upenn.edu ) 11 2 2004 © 2004. 2004 Zebrafish nic1 Motor axon En passant terminals Synaptogenesis Acetylcholine receptor α-subunit chrna1 Slow-channel congenital myasthenic syndrome twister It is well-established that synaptic connections between...

... system and then disrupted endocytosis at various times during development. The giant fiber retracted its axon or incipient synapses when endocytosis was blocked at critical times, and we perceived four phases to giant fiber development: an early pathfinding phase, an intermediate phase of synaptogenesis...

... of spontaneous activity in embryonic hippocampal slices. Further, BDNF dramatically increases spontaneous co-active network activity, which is believed to synchronize gene expression and synaptogenesis in vast numbers of neurons. In fact, BDNF raises the spontaneous activity of E18 hippocampal neurons to levels...

... component of this regulatory machinery is a retrograde signal from the postsynaptic cell that mediates the formation of synaptic connections. Synaptogenesis Activity Synaptic plasticity Neuromuscular junction Retrograde signal C. elegans Patterns of neural activity play essential roles...

... in subtle defects in a longitudinal axon pathway in the embryonic central nervous system. Concomitant loss of both maternally and zygotically derived Dock dramatically enhances these central nervous system defects, but does not increase the delay in RP3 synaptogenesis. These results indicate that Dock...

...Brian Wolf; Mark A. Seeger; Akira Chiba ABSTRACT We show that the Commissureless (COMM) transmembrane protein is required at neuromuscular synaptogenesis. All muscles in the Drosophila embryo express COMM during the period of motoneuron-muscle interaction. It is endocytosed into muscles before...

... by Company of Biologists 1997 cell adhesion chemoaffinity Fasciclin III growth cone homophilic Ig-CAM synaptogenesis target recognition Drosophila The final step of axon guidance is marked by mutual recog-nition between a growth cone and its synaptic target. This synaptic target...

..., including those that are normally Toll- positive. In contrast, heterochronic misexpression of Toll in the musculature leads to the same growth cone reaching its correct target region but delaying synaptic initiation. We propose that Toll acts locally to inhibit synaptogenesis of specific motoneuron growth...

... target but before it has started to send out branches. NO sensitivity typically ends as synaptogenesis is nearing completion. Data from interneurones and sensory neurones are also consistent with the hypothesis that NO sensitivity appears as a developing neurone changes from axonal outgrowth...