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Keywords: Synapse
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (8): dev200425.
Published: 3 May 2022
... – brain-specific, yolk sac-derived macrophages – in neural development, highlighting temporal and spatial heterogeneity in their interactions with neuronal and non-neuronal cells to support brain development and regeneration. Microglia Brain development Heterogeneity Neurons Synapse...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2022) 149 (9): dev200045.
Published: 3 May 2022
... synapse. Here, we tested whether these RNA-binding proteins act jointly in a common mechanism. We found that both dfmr1 and staufen mutants, and trans-heterozygous double mutants, displayed increased synaptic bouton formation and GluRIIA accumulation. With cell-targeted RNA interference, we showed...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (12): dev194951.
Published: 28 June 2021
... of the master astrocytic gene Nfia . Moreover, PHF8 regulates key synaptic genes in astrocytes by maintaining low levels of H4K20me3. Accordingly, astrocytic-PHF8 depletion has a striking effect on neuronal synapse formation and maturation in vitro . These data reveal that PHF8 is crucial in astrocyte...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev186312.
Published: 21 May 2020
...Sarah Perry; Pragya Goel; Nancy L. Tran; Cristian Pinales; Christopher Buser; Daniel L. Miller; Barry Ganetzky; Dion Dickman ABSTRACT Synapses exhibit an astonishing degree of adaptive plasticity in healthy and disease states. We have investigated whether synapses also adjust to life stages imposed...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (13): 2310–2322.
Published: 1 July 2017
..., cell migration, neuronal polarization and synapse formation. * Author for correspondence ( gerhard.schratt@staff.uni-marburg.de ) Competing interests The authors declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 Summary...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2017) 144 (13): 2445–2455.
Published: 1 July 2017
... of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner. Both myostatin and GDF11 affected synapse formation in isolated rat cortical neuron cultures, suggesting an effect on synaptogenesis beyond...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1346–1356.
Published: 1 April 2015
.... B. , Carroll , R. C. and Bassell , G. J. ( 2004 ). Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses . J. Neurosci.   24 , 2648 - 2655 . 10.1523/JNEUROSCI.0099-04.2004...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (9): 1864–1874.
Published: 1 May 2014
...Carlos M. Loya; Elizabeth M. McNeill; Hong Bao; Bing Zhang; David Van Vactor MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play important roles in nervous system development and physiology. However, our understanding of the strategies by which miRNAs control synapse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2237–2250.
Published: 1 July 2010
... understood. Here, we report the function of a nuclear pre-mRNA 3′-end processing pathway in synapse and axon formation in C. elegans. In a genetic enhancer screen for synaptogenesis mutants, we identified a novel polyproline-rich protein, Synaptic defective enhancer-1 (SYDN-1). Loss of function of sydn-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2139–2146.
Published: 1 July 2010
... innervate M12 (MN12s) formed smaller synapses on M12 and instead appeared to form ectopic nerve endings on M13. Conversely, ectopic expression of Toll in M12 inhibited synapse formation by MN12s. These results suggest that Toll functions in M13 to prevent synapse formation by MN12s. We identified Tey...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (15): 2669–2679.
Published: 1 August 2008
... of their synapses and cell bodies in late pupal and adult animals. In this model, synapse loss is caused by reactive oxygen species(ROS) production, not energy depletion, as ATP levels are normal in mutant photoreceptors, and both pharmacological and targeted genetic manipulations that reduce ROS levels prevent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (13): 2477–2486.
Published: 1 July 2006
... the development of neuronal connectivity by influencing presynaptic retinal ganglion cell (RGC) axons. Increasing BDNF levels in the optic tectum of Xenopus tadpoles significantly increases both axon arborization and synapse density per axon terminal within a few hours of treatment. Here, we have further explored...
Journal Articles
Journal: Development
Development (2003) 130 (11): 2291–2301.
Published: 1 June 2003
...Marco Leu; Elena Bellmunt; Martin Schwander; Isabel Fariñas; Hans Rudolf Brenner; Ulrich Müller Neuregulins and their Erbb receptors have been implicated in neuromuscular synapse formation by regulating gene expression in subsynaptic nuclei. To analyze the function of Erbb2 in this process, we...
Journal Articles
Journal: Development
Development (2001) 128 (24): 5005–5015.
Published: 15 December 2001
... mutant (bottom) larva. The NMJs of muscles 6 and 7 of abdominal segment 2 are shown. The localization of Dlg, Lgl and GluRIIB are shown. In amph mutants, Lgl is absent from the synapse but still maintained in the M band of the muscle. GluRIIB protein localization at the NMJ is identical in wild type...
Journal Articles
Journal: Development
Development (1986) 94 (1): 149–161.
Published: 1 June 1986
..., but significantly smaller in magnitude. In the present study, topographic postsynaptic units could be recorded at all stages investigated, indicating functional synapses between the optic nerve fibres and the tectum. Thus, these studies offer evidence of a significant shift in the functional connection pattern...