... attributed. Highlighted Article: Autonomous anteroposterior polarization in aggregates of mouse embryonic stem cells illustrates how alternative initial cell states between the embryo and the aggregates may converge onto similar fates. Anteroposterior axis Symmetry breaking Embryonic...

...Minh-Son Phan; Jang-mi Kim; Cara Picciotto; Lydie Couturier; Nisha Veits; Khallil Mazouni; François Schweisguth ABSTRACT Lateral inhibition mediates alternative cell fate decision and produces regular cell fate patterns with fate symmetry breaking (SB) relying on the amplification of small...

... as case studies. X-chromosome inactivation Epigenetic memory Monoallelic expression Olfactory receptors Symmetry breaking European Research Council http://dx.doi.org/10.13039/100010663 948771 Helen Hay Whitney Foundation http://dx.doi.org/10.13039/100005237...

... Notch1a-determined symmetry breaking buffers rotational noise. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: Steve Wilson Competing interests The authors declare no competing or financial interests. 6...

... polarity Embryonic axis Symmetry breaking Embryonic regulation Regeneration Summary: Two adjacent extra-embryonic tissues, the area opaca and the marginal zone, interact to influence the polarity of the early chick embryo. © 2022. Published by The Company of Biologists Ltd 2022...

... that govern the initiation, maintenance and directionality of efficient migration in single and collective cells, independently of external regulators. Cell migration Self-organization Symmetry breaking The ability of cells to migrate is an underlying principle that governs various biological...

... collectively by cell-cell communication as a novel inhomogeneous state of the coupled system. Differentiation can be triggered by cell number increase as the population grows in size, through organisation of the initial homogeneous population before the symmetry-breaking bifurcation point. Robust proportioning...

.... Mechanical stress Symmetry breaking Tissue morphodynamics Branching morphogenesis begins with a simple tube or cluster of cells that grows and undergoes rounds of budding and/or bifurcation, leading to the formation of a complex, arborized network. The final form and function of each branched organ...

...Naor Sagy; Shaked Slovin; Maya Allalouf; Maayan Pour; Gaya Savyon; Jonathan Boxman; Iftach Nachman ABSTRACT During early embryogenesis, mechanical constraints and localized biochemical signals co-occur around anteroposterior axis determination and symmetry breaking. Their relative roles, however...

... from the analysis of symmetry breaking both in vivo and from reconstituted systems. Some symmetry-breaking events seem cell-autonomous, being determined parentally or encoded in asymmetric gene expression among the cells of a very early embryo. Other symmetry-breaking events are caused by a morphogen...

... axial organisation. Here, we report that small aggregates of mESCs, of about 300 cells, self-organise into polarised structures that exhibit collective behaviours reminiscent of those that cells exhibit in early mouse embryos, including symmetry breaking, axial organisation, germ layer specification...