... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. STAT genes are widely conserved in metazoans, from the slime mold Dictyostelium discoideum , the nematode Caenorhabditis elegans and the fruit fly Drosophila...

... and base of the cochlea, P <0.01). Misexpression of Neurog1 increased survival preferentially of IHCs, with the greatest reduction in the third row of OHCs ( Fig. 2 C-D‴, Fig. 3 B,E). Previous work on self-terminating Atoh1 conditional null mice ( Pan et al., 2012a ) and Atoh1 hypomorphs...

...Xiaoyan Sheng; Yun C. Yung; Allison Chen; Jerold Chun Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation...

... cell survival but is dispensable for fiber cell differentiation during lens development. Our data indicate that MAPK1/3 control cell proliferation in the lens epithelium in a spatially defined manner; MAPK1 plays a unique role in establishing the highly mitotic zone in the peripheral region, whereas...

... the hematopoietic-specific requirement of c-Myc in the embryo proper and provide in vivo evidence to support a synergism between hematopoietic and liver development. Our results reveal for the first time that physiological levels of c-Myc are essential for cell survival and demonstrate that, in contrast to most...

...Yvette G. Langdon; Sarah C. Goetz; Anna E. Berg; Jackie Thomas Swanik; Frank L. Conlon The isolation and culturing of cardiac progenitor cells has demonstrated that growth factor signaling is required to maintain cardiac cell survival and proliferation. In this study, we demonstrate in Xenopus...

... was expressed primarily in the germ cells before and after follicle formation. Mouse neonatal and fetal ovaries and human fetal ovaries were cultured in the presence of K252a, a potent inhibitor of all Trk receptors. In mice, K252a inhibited the survival of germ cells in newly formed(primordial) follicles...

...Stone Elworthy; James A. Lister; Tom J. Carney; David W. Raible; Robert N. Kelsh The transcription factor Sox10 is required for the specification, migration and survival of all nonectomesenchymal neural crest derivatives including melanophores. sox10 -/- zebrafish lack expression...

...Gwendolen E. Booth; Edward F. V. Kinrade; Alicia Hidalgo ABSTRACT While survival of CNS neurons appears to depend on multiple neuronal and non-neuronal factors, it remains largely unknown how neuronal survival is controlled during development. Here we show that glia regulate neuronal survival...

... Nüsslein-Volhard ABSTRACT Neural crest development involves cell-fate specification, proliferation, patterned cell migration, survival and differentiation. Zebrafish neural crest derivatives include three distinct chromatophores, which are well-suited to genetic analysis of their development. As part...

... sensitivity in some neurons. 07 01 1994 © 1994 by Company of Biologists 1994 p75 neurotrophins survival mouse Nerve growth factor (NGF; Levi-Montalcini, 1987 ) is a member of a gene family of neurotrophic factors (neu-rotrophins) that includes brain-derived neurotrophic factor...