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Keywords: Supporting cells
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Journal Articles
Rac1 and Nectin3 are essential for planar cell polarity-directed axon guidance in the peripheral auditory system
Available to PurchaseIn collection:
Review Commons Transfers
Shaylyn Clancy, Nicholas Xie, Tess Eluvathingal Muttikkal, Jasmine Wang, Aray Adylkhan, Esha Fateh, Margaret Smith, Phillip Wilson, Matthew Smith, Arielle Hogan, Ann Sutherland, Xiaowei Lu
Journal:
Development
Series: REVIEW COMMONS TRANSFER
Development (2025) 152 (8): dev204423.
Published: 24 April 2025
... in the cochlear epithelium to guide SGNII peripheral afferent turning. However, the underlying mechanisms are unknown. Here, we show that PCP signaling regulates junctional localization of the small GTPase Rac1 and the cell adhesion molecule Nectin3 in mouse cochlear supporting cells (SCs), which serve...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2022) 149 (8): dev200113.
Published: 3 May 2022
...-related genes and confirmed with single-cell RNA-sequencing that these changes occur in supporting cells. In situ hybridization was used to further validate these findings. We determined that the JAK/STAT signaling pathway is essential for upregulation of the damage-response genes in supporting cells...
Includes: Supplementary data
