.../ Summary: mRNA electroporation is a powerful new method for functional studies in neonatal and adult neural stem cells as well as postmitotic neurons. Adult neurogenesis Subventricular zone Olfactory bulb Cortex Dicer microRNA pathway Manipulation of gene expression in the brain...

... cell (NSC) quiescence and growth. Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche signal in the subventricular zone (SVZ) of the lateral ventricle of the adult mouse brain. sAPP suppresses NSC growth in culture. Further in vivo studies on the role of APP...

... subclasses. We recently showed that MEIS2 cooperates with the neurogenic transcription factor PAX6 in the control of adult subventricular zone (SVZ) neurogenesis in rodents. Expression of the PBC protein PBX1 in the SVZ has been reported, but its functional role(s) has not been investigated. Using a genetic...

... that was presented at the Fusion meeting on Adult Neurogenesis, which was held in March 2016 in Cancun, Mexico. Adult neurogenesis Hippocampus Human pluripotent stem cell Neural stem cell Neurological disease Subventricular zone The human brain is complex, with millions of neuronal subtypes...

...Roberto Fiorelli; Kasum Azim; Bruno Fischer; Olivier Raineteau Neurogenesis does not stop abruptly at birth, but persists in specific brain regions throughout life. The neural stem cells (NSCs) located in the largest germinal region of the forebrain, the ventricular-subventricular zone (V-SVZ...

...Namasivayam Ravi; Zhijun Li; Lars-Lennart Oettl; Dusan Bartsch; Kai Schönig; Wolfgang Kelsch New granule cell neurons (GCs) generated in the neonatal and adult subventricular zone (SVZ) have distinct patterns of input synapses in their dendritic domains. These synaptic input patterns determine...

... expressed in neuroblasts of the subventricular zone (SVZ) and rostral migratory stream (RMS) and in some of the OB interneurons that are continuously replaced during adult life. Targeted manipulations with retroviral vectors expressing function-blocking forms or with small interfering RNAs demonstrated...

... ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Adult neurogenesis Cerebral cortex Neuronal specification Olfactory bulb Subventricular zone In the developing telencephalon...

...Alfonso Lavado; Guillermo Oliver Ependymal cells are part of the neurogenic niche in the adult subventricular zone of the lateral ventricles, where they regulate neurogenesis and neuroblast migration. Ependymal cells are generated from radial glia cells during embryonic brain development...

... cells and a small subset of astrocytes in the adult stem cell niche. Subventricular zone Adult stem cell niche Ependymal cells Astrocytes FoxJ1 Mouse The developing neuroepithelium consists of multipotent stem cells with radial glial features ( Campbell and Gotz, 2002 ; Noctor et al...

... expressed in situ by stem/progenitor cells of the two neurogenic regions of the adult murine brain:the subventricular zone (type B cells) and the dentate gyrus of the hippocampus (residual radial glia). We explored the possibility that adult multipotent neural stem cells express nucleotide receptors...

... the striatal subventricular zone and differentiation of late born striatal neurons. Neuron 19 , 27 -37. Appel, B., Givan, L. A. and Eisen, J. S. ( 2001 ). Delta-Notch signaling and lateral inhibition in zebrafish spinal cord development. BMC Dev. Biol. 1 , 13 . Bauer, S., Rasika, S., Han, J...

... respond to Shh signaling in stem cell niches. Here we demonstrate that Shh is required for cell proliferation in the mouse forebrain's subventricular zone (SVZ) stem cell niche and for the production of new olfactory interneurons in vivo. We identify two populations of Gli1 + Shh signaling responding...

... CNS neural precursor differentiation in pathological conditions. Mol. Cell. Neurosci. 19 , 225 -238. Doetsch, F., Caille, I., Lim, D. A., Garcia-Verdugo, J. M. and Alvarez-Buylla, A. ( 1999 ). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell . 97 , 703...

... to a non-surface (NS)position, the subventricular zone (SVZ), within a single cell-cycle length while keeping the other mitotic daughter for division at the surface. The NS-dividing cells were mostly Hu + and their daughters were also Hu + , suggesting their commitment to the neuronal lineage and supply...

... and increases the in vitro proliferation of embryonic neural stem cells. As neurogenesis is an ongoing process in the adult mammalian brain, we have investigated a role for sAPP in adult neurogenesis. We show that the subventricular zone (SVZ) of the lateral ventricle, the largest neurogenic area of the adult...

... alleles results in a notable decrease in precursor cell number, particularly in the subventricular zone. Slides were rapidly immersed in a solution of 0.5% Toluidine Blue in dH 2 O and subsequently washed in dH 2 O until staining was considered optimal. Slides were then quickly taken through a series...

.... *Author for correspondence (e-mail: [email protected] ) 8 3 2001 © 2001. 2001 Cell migration Cortical plate Corticogenesis Differentiation Neocortex Otx1 Pax6 Small eye mutant Subventricular zone The cerebral cortex of the mammalian brain consists of six...

... the subventricular zone (SVZ), and produced an augmentation of glial progeny in the neo-and archicortex. However, activated Notch1 had a distinct effect on the progenitors of the olfactory bulb, markedly reducing the numbers of cells of any type that migrated there. To elucidate the mechanism of the cell fate...

... through the subventricular zone. Some of these LGE-derived cells invade the cortical plate and express GABA, while others remain within the cortical proliferative zone and appear to become mitotically active late in gestation. In addition, by comparing the phenotypes of mouse mutants with differential...