...Zihao Su; Ziwu Wang; Susan Lindtner; Lin Yang; Zicong Shang; Yu Tian; Rongliang Guo; Yan You; Wenhao Zhou; John L. Rubenstein; Zhengang Yang; Zhuangzhi Zhang ABSTRACT The striatum is a central regulator of behavior and motor function through the actions of D1 and D2 medium-sized spiny neurons (MSNs...

... (D1 MSNs) and dopamine receptor DRD2-expressing medium spiny neurons (D2 MSNs) are the principal projection neurons in the striatum, which is divided into dorsal striatum (caudate nucleus and putamen) and ventral striatum (nucleus accumbens and olfactory tubercle). Progenitors of these neurons arise...

... (hESCs) and induced pluripotent stem cells (hiPSCs) is fundamental for realising their promise in disease modelling, pharmaceutical drug screening and cell therapy for Huntington's disease. GABAergic medium-sized spiny neurons (MSNs) are the principal projection neurons of the striatum and specifically...

... quiescent neuronal progenitors occur in other brain regions is unclear. Here, we describe a novel neurogenic system in the external capsule and lateral striatum (EC-LS) of the juvenile guinea pig that is quiescent at birth but becomes active around weaning. Activation of neurogenesis in this region...

... of the basal ganglia, the striatum, contains two classes of neurons: the principal population of medium-sized dense spiny neurons (MSNs; 97-98% of all striatal neurons in rodents), which project to the globus pallidus and the substantia nigra, and the locally projecting striatal interneurons (SINs; 2-3...

...Lara Passante; Nicolas Gaspard; Mélanie Degraeve; Jonas Frisén; Klas Kullander; Viviane De Maertelaer; Pierre Vanderhaeghen Brain structures, whether mature or developing, display a wide diversity of pattern and shape, such as layers, nuclei or segments. The striatum in the mammalian forebrain...

... on gain-of-function approaches because perturbation of Notch signaling results in death prior to the onset of neurogenesis. Here, we examine the requirement for Notch signaling in the development of the striatum through the analysis of different single and compound Notch1 conditional and Notch3 null...

...Ronald R. Waclaw; Bei Wang; Kenneth Campbell We have examined the role of the homeobox gene Gsh2 in retinoid production and signaling within the ventral telencephalon of mouse embryos. Gsh2 mutants exhibit altered ventral telencephalic development,including a smaller striatum with fewer DARPP-32...

... Telencephalon Notch signaling LGE Striatum Radial glia Neurogenesis Mouse Early development of the central nervous system (CNS) involves specification of progenitor cells to generate the anlagen of CNS subdivisions and precursors of distinct cells types( Jessell, 2000 ; Briscoe and Ericson, 2001...

... Gsh2 Pax6 Telencephalon Dorsoventral patterning LGE Ventral pallium Striatum Pallial/subpallial boundary CNS development Mouse In the last decade, significant inroads have been made into elucidating mechanisms that regulate dorsoventral (D/V) patterning in the mammalian spinal cord...

...Håkan Toresson; S. Steven Potter; Kenneth Campbell ABSTRACT We have examined the genetic mechanisms that regulate dorsal-ventral identity in the embryonic mouse telencephalon and, in particular, the specification of progenitors in the cerebral cortex and striatum. The respective roles of Pax6...

... Boundary Cerebral cortex Striatum Ganglionic eminence GABA Calbindin Calretinin Adenovirus Green fluorescent protein Mouse During the development of the central nervous system, distinct regions must be specified and delineated from one other. Most insights into the mechanisms that underlie...

... in the murine embryonic striatum, where it is the only gene of the family to be expressed. Ebf1 targeted disruption affects postmitotic cells that leave the subventricular zone (SVZ) en route to the mantle: they appear to be unable to downregulate genes normally restricted to the SVZ or to activate some mantle...

... ganglionic eminence. Using this approach, the homeobox gene Meis2 was found highly expressed in the lateral ganglionic eminence and developing striatum. Since Meis2 has recently been shown to be upregulated by retinoic acid in P19 EC cells (Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Sapin, V., Chambon...

... cells dissociated from the embryonic striatum and implanted into the brain of embryos of the same species generate cells that reaggregate to form easily recognizable structures that we previously called clusters and cells that disperse and integrate as single cells into the host brain. We sought...

... patterning cortex striatum radial glia RC2 tenascin-C The molecular mechanisms that generate regional and cellular diversity in the developing central nervous system are largely unknown. Transcription factors, signalling and adhesion molecules are all likely to be involved in these mechanisms...

... by Altman and Bayer (1990b) . Using [ 3 H]thymidine labeling alone, it is not possible to determine the origins of the cells in these cortical bands, nor whether they constitute spatially restricted groups of proliferating clones. In the striatum, no distinct [ 3 H]thymidine bands or any obvious pattern...