... and Barnes, 2000 ). Despite the high frequency at which spontaneous DNA damage occurs, we have very limited understanding of how cells react to this stress during development. DNA damage Single cell transcriptomics Stochastic gene expression Dictyostelium Cell-cell adhesion Summary...

... expression coupled to global transcriptome changes shared by all cells. Single cell transcriptomics Stochastic gene expression Symmetry-breaking Dictyostelium Attractor state MS2 At its most rudimentary, a self-organising developmental system is one in which a single cell or unstructured...

... of a Nanog reporter is coupled to various cell- and population-based features in mouse embryonic stem cells. Nanog Rex1 Zfp42 Heterogeneity High-content imaging Stochastic gene expression Stem cell Spatial and temporal accuracy of gene expression programmes is central to cell choices...

... ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Chimaera Developmental plasticity Regulative development Stochastic gene expression Twin One of the most intriguing observations...