...Christian F. Christensen; Takashi Koyama; Stanislav Nagy; E. Thomas Danielsen; Michael J. Texada; Kenneth A. Halberg; Kim Rewitz ABSTRACT The activation of a neuroendocrine system that induces a surge in steroid production is a conserved initiator of the juvenile-to-adult transition in many animals...

... Drosophila ovarian germline stem cell niche formation, the status of Notch signaling in the cell can be reprogrammed. This is controlled via steroid-induced miR-125 , which targets a negative regulator of Notch signaling, Tom. Thus, miR-125 acts as a spatiotemporal coordinator between paracrine Notch...

... to differentiation of the terminal chamber. Finally, the steroid hormone ecdysone controls cardiac tube remodelling by impinging on both the regulation of Ubx expression and the modification of AbdA function. Our results shed light on the genetic control of one in vivo occurring remodelling process, which involves...

... in either of two genes, NPC1 , which encodes a transmembrane protein related to the Hedgehog receptor Patched, and NPC2 , which encodes a secreted cholesterol-binding protein. Npc1 mutant mice can be partially rescued by treatment with specific steroids. We have created a Drosophila NPC model by mutating...

... this type of cell death. Here we show that steroid-activated programmed cell death of Drosophila salivary glands occurs by autophagy. Expression of p35 prevents DNA fragmentation and partially inhibits changes in the cytosol and plasma membranes of dying salivary glands, suggesting that caspases...

... during metamorphosis, when muscles are reorganized to support adult structures and behavior. These embryonic and metamorphosis defects are similar to the phenotypes produced by previously identified genes that function in either muscle development or steroid signaling pathways. who transcription occurs...