... but led to sternum ossification defects as a result of defective generation of Runx2 + pre-osteoblasts. Conditional and temporal Ebf3 knockout mice revealed requirements of Ebf3 in the lateral plate mesenchyme cells (LPMs), especially in tendon/muscle connective tissue cells, and a stage-specific Ebf3...

.... Requirement for Dchs1-Fat4 signaling in internal organs. Paired mutant and wild-type images are always at the same magnification. ( A-D ) Sternums from P0 skeletal preparations of the indicated genotypes, stained with Alcian Blue (for cartilage) and Alizarin Red (for bone). ( E ) Histogram of average length...

...) DKO mice, respectively]. Prx1 Runx1 f/f mice displayed a delay in sternal development and Prx1 DKO mice completely lacked a sternum. By contrast, α 1(II) Runx1 f/f mice and α 1(II) DKO mice did not show any abnormal sternal morphogenesis or chondrocyte differentiation. Notably, Runx1, Runx2...

...-catenin/Wnt signaling in dermal development. * Author for correspondence (e-mail: [email protected] ) 10 5 2008 © 2008. 2008 Dermis Cell fate Cell survival Skin Sternum Identifying the molecular controls of dermal cell fate from diverse origins in the mammalian embryo...

... and cerebellum were missing and the third and fourth cranial nerves were absent. A deletion of mid-hindbrain tissue was observed as early as 9.5 days of embryonic development and the phenotype resembles that previously reported for Wnt - 1 mutant mice. In addition, patterning of the forelimb paws and sternum...