... is defined by the ‘bare zone’, a microvilli-free sub-region of apical membrane specified by the Insc-LGN-Gαi protein complex. We now report that LGN and Gαi also occupy the very tip of stereocilia that directly abut the bare zone. We demonstrate that LGN and Gαi are both essential for promoting...

... that orbiter/pcdh15a encodes a component of the stereociliary bundle. The large extracellular domain of Pcdh15a, along with the localization data from mammals, suggests that Pcdh15a may be part of the outer membrane calyx or a component of the extracellular links spanning neighboring stereocilia. Although...

... cell development in the inner ear. We describe the effects of three mutations on cochlear hair cell development and function. In the Myo7a 816SB and Myo7a 6J mutants, stereocilia grow and form rows of graded heights as normal, but the bundles become progressively more disorganised. Most...

...Lewis G. Tilney; Douglas A. Cotanche; Mary S. Tilney ABSTRACT Beginning in 8-day embryos, stereocilia sprout from the apical surface of hair cells apparently at random. As the embryo continues to develop, the number of stereocilia increases. By 10 1/2 days the number is approximately the same...