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Keywords: Stem cells
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Journal Articles
Journal: Development
Development (2022) 149 (8): dev199903.
Published: 3 May 2022
... the ability of cells outside of the adaptive immune system to respond to recurring infections through the lens of evolution and cellular memory. With this in mind, we then discuss the bidirectional crosstalk between the immune cells and stem cells and present examples where these interactions regulate tissue...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev197947.
Published: 31 March 2022
... ). This behavior is coupled with changes in gene expression, such that cells at the leading edges express sonic hedgehog (Shh), which later become the hair matrix, and those trailing behind express Sox9, which later become the hair follicle stem cells. The flow displaces the dermal condensates (a cluster...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200115.
Published: 31 March 2022
...Viju Vijayan Pillai; Tiffany G. Kei; Shailesh Gurung; Moubani Das; Luiz G. B. Siqueira; Soon Hon Cheong; Peter J. Hansen; Vimal Selvaraj ABSTRACT Exponential proliferation of trophoblast stem cells (TSC) is crucial in Ruminantia to maximize numerical access to caruncles, the restricted uterine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev192914.
Published: 15 December 2021
... stem cells that are easy to access, track, manipulate and scale. Here, we explain how unlocking distinct levels of embryo-like architecture through controlled modulations of the cellular environment enables the identification of minimal sets of mechanical and biochemical inputs necessary to pattern...
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199683.
Published: 9 November 2021
... stem cells of small intestinal (SI) crypts. To examine NF–κB functions in SI epithelial self-renewal, mice or SI crypt organoids (‘mini-guts’) with ubiquitously suppressed NF-κB activity were used. We show that NF-κB activity is dispensable for maintaining SI epithelial proliferation, but is essential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199909.
Published: 28 October 2021
...: from fertilisation to blastocyst. Furthermore, we highlight current advances in elucidating the significance of specific microtubule arrays in in vitro culture systems of pluripotent stem cells and how the microtubule cytoskeleton serves as a highway for the precise intracellular movement of organelles...
Journal Articles
Journal: Development
Development (2021) 148 (15): dev186387.
Published: 3 August 2021
... biology community in recent years. Overall, this Primer provides a concise overview of how micropatterns are used to study developmental processes and emphasises how micropatterns are a useful addition to the developmental biologist’s toolbox. Pluripotent stem cells (PSCs) are self-renewing cell...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev186106.
Published: 9 March 2021
...Meghan Ferguson; Kristina Petkau; Minjeong Shin; Anthony Galenza; David Fast; Edan Foley ABSTRACT Microbial factors influence homeostatic and oncogenic growth in the intestinal epithelium. However, we know little about immediate effects of commensal bacteria on stem cell division programs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev189753.
Published: 9 March 2021
...Liang Zhang; Daniel DeGennaro; Guangzhong Lin; Jijie Chai; Elena D. Shpak ABSTRACT The shoot apical meristem (SAM) is a reservoir of stem cells that gives rise to all post-embryonic above-ground plant organs. The size of the SAM remains stable over time owing to a precise balance of stem cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev165084.
Published: 8 February 2021
...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193458.
Published: 18 January 2021
.... Elucidating the cellular players and their regulation mechanisms provides fundamental information to deepen understanding about the responses and contributions of lung stem cells. This Review focuses on advances in our understanding of mammalian alveolar epithelial stem cell subpopulations and discusses...
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (24): dev189746.
Published: 24 December 2020
... series of events. However, the human retina shows many differences from that of other organisms and the investigation of human eye development now benefits from stem cell-derived organoids. Retinal differentiation methods have progressed from simple 2D adherent cultures to self-organising micro...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev169862.
Published: 15 November 2020
... different cell fates. Fig. 2. A proposed cellular hierarchy model of mammary stem and progenitor cells. Lineage-tracing studies suggest that multipotent mammary epithelial stem cells are predominantly active during embryonic stages of development. By birth, although some fMaSCs remain and may...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev194100.
Published: 15 November 2020
...Pooja Flora; Elena Ezhkova ABSTRACT Cell divisions and cell-fate decisions require stringent regulation for proper tissue development and homeostasis. The mammalian epidermis is a highly organized tissue structure that is sustained by epidermal stem cells (ESCs) that balance self-renewal and cell...
Journal Articles
Journal: Development
Development (2020) 147 (20): dev193888.
Published: 26 October 2020
... developmental potential of neural crest cells originating in the head. Here, we explore how recent studies of experimental embryology, genetic circuits and stem cell differentiation have shaped our understanding of the mechanisms that establish axial-specific populations of neural crest cells. Additionally, we...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev192807.
Published: 9 October 2020
... experiments with a model of severe glandular injury in the mouse submandibular gland, we show that de novo formation of acini involves induction of cellular plasticity in multiple non-acinar cell populations. Fate-mapping analysis revealed that, although ductal stem cells marked by cytokeratin K14 and Axin2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (19): dev185975.
Published: 9 October 2020
... oculis-related homeobox Six1 - Six6 genes in vertebrates. Six1 , Six2 , Six4 and Six5 are expressed in the muscle lineage. Here, we tested the hypothesis that Six1 and Six4 could participate in the genesis of myogenic stem cells. We show that fewer PAX7+ cells occupy a satellite cell position between...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev182725.
Published: 24 August 2020
.... Developmental biology Differentiation circRNAs Noncoding RNAs Stem cells Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules that were identified many years ago but have only recently attracted the attention of the general scientific community. They were initially described...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev188987.
Published: 19 June 2020
...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Nicola Facchinello; Andrea Vettori; Giorgio Licciardello; Natascia Tiso; Francesco Argenton ABSTRACT The transcription factor Stat3 is required for proliferation and pluripotency of embryonic stem cells; we have prepared...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev189472.
Published: 8 June 2020
...Vasilia Tamamouna; Myrofora Panagi; Andria Theophanous; Maria Demosthenous; Maria Michail; Markella Papadopoulou; Savvas Teloni; Chrysoula Pitsouli; Yiorgos Apidianakis ABSTRACT Systemic and stem cell niche-emanating cytokines and growth factors can promote regeneration, through mitosis. High...
Includes: Supplementary data