... for extended periods of time ( Fuchs and Blau, 2020 ). Quiescence is an actively maintained property, requiring multiple signals provided by the stem cell niche ( Urbán and Cheung, 2021 ; van Velthoven and Rando, 2019 ). Cell-cell and cell-matrix adhesion between stem cells and their niche are important...

... signalling in the cell population. Cell state transition Positive feedback MS2 imaging Stem cell niche Oscillation Transcriptional noise Optogenetics Collective behaviour In vivo imaging Excitable signalling Wellcome Trust http://dx.doi.org/10.13039/100010269 202867/Z/16/Z...

... undergo large scale remodeling involving stem cells, transient amplifying cells and differentiated cells. The control of this homeostasis in physiological and plucked-induced cycling is analyzed. Stem cell niche Dermis Follicle Morphogenesis Evolution Evo-Devo Chicken National...

... epithelial invagination, and decreases progenitor cell proliferation and dental epithelium cell differentiation. Developmentally, Pitx2 regulates formation of the Sox2 + labial cervical loop (LaCL) stem cell niche in concert with two signaling centers: the initiation knot and enamel knot. The loss of Pitx2...

...-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type. * Author for correspondence ( [email protected] ) Competing interests The authors declare no competing or financial interests. © 2019...

... , important components of the male and female gonad stem cell niches (hubs and terminal filaments/cap cells, respectively) still form. Initially, gonads in all dsx mutants (both XX and XY) initiate the male program of development, but later half of these gonads switch to form female stem cell niche structures...

.../j.cub.2007.02.027 Chen , S. , Wang , S. and Xie , T. ( 2011 ). Restricting self-renewal signals within the stem cell niche: multiple levels of control . Curr. Opin. Genet. Dev.   21 , 684 - 689 . 10.1016/j.gde.2011.07.008 Clegg , N. J. , Honda , B. M...

... population in the ventricular-subventricular zone (V-SVZ). An essential, but understudied, contributor to V-SVZ stem cell niche health is the multi-ciliated ependymal epithelium, which replaces stem cells at the ventricular surface during development. However, reorganization of the V-SVZ stem cell niche...

...-generated reagents. (A) Schematic of the stem cell niche of the Drosophila testis tip. Zfh1 (magenta) marks the nuclei of the CySCs and, at lower levels, their immediate progeny. (B) CySCs are recognised by their Zfh1 + nuclei (blue) and their position adjacent to the hub (identified by strong DE-Cad...

.... Target of rapamycin protein kinase Nutrient signaling Metabolism reprogramming Cell cycle regulation Meristem Stem cell niche Emerging evidence supports the notion that signaling and metabolic networks are intertwined and play instructive roles in developmental programs and responses...

...Andrew W. Allbee; Diego E. Rincon-Limas; Benoît Biteau ABSTRACT The Drosophila ovary serves as a model for pioneering studies of stem cell niches, with defined cell types and signaling pathways supporting both germline and somatic stem cells. The establishment of the niche units begins during...

...Andriy S. Yatsenko; Halyna R. Shcherbata ABSTRACT Stem cell niches act as signaling platforms that regulate stem cell self-renewal and sustain stem cells throughout life; however, the specific developmental events controlling their assembly are not well understood. Here, we show that during...

... signaling pathways guide the maintenance, differentiation and proliferation of somatic and germline stem cells of the Drosophila germarium. Yorkie Hedgehog signaling Stem cell niche Drosophila ovary Escort cell National Institutes of Health 10.13039/100000002 GM079351...

... with the undisturbed emerging LRP. By alternating auxin and cytokinin treatments, we showed that the root and shoot organogenetic programs are remarkably plastic, as the status of the same plant stem cell niche can be reversed repeatedly within a set developmental window. Thus, the networks at play in the meristem...

...Lindsey Wingert; Stephen DiNardo The niche directs key behaviors of its resident stem cells, and is thus crucial for tissue maintenance, repair and longevity. However, little is known about the genetic pathways that guide niche specification and development. The male germline stem cell niche...

...Kanako Ikami; Moe Tokue; Ryo Sugimoto; Chiyo Noda; Satoru Kobayashi; Kenshiro Hara; Shosei Yoshida Stem cells ensure tissue homeostasis through the production of differentiating and self-renewing progeny. In some tissues, this is achieved by the function of a definitive stem cell niche. However...

...Tom Bennett; Albert van den Toorn; Viola Willemsen; Ben Scheres The regulation of columella stem cell activity in the Arabidopsis root cap by a nearby organizing centre, the quiescent centre, has been a key example of the stem cell niche paradigm in plants. Here, we investigate interactions between...

... 2013 Hair Dermal papilla Stem cell niche The hair shaft is formed from keratinocytes derived from a progenitor population at the base of the hair follicle during the anagen or growth phase of the hair cycle. The dermal papilla (DP) serves as a physical niche for these matrix...

... represented. Perhaps more than at previous Keystone meetings, this provided a broad overview of the diversity of SCs, as well as their commonalities, emerging themes and the requirements for their future study. Regeneration Reprogramming Stem cell niche © 2012. 2012 Competing interests...

[email protected] ) Competing interests statement The authors declare no competing financial interests. 11 2 2011 © 2011. 2011 Dedifferentiation Gonadogenesis Stem cell niche Drosophila Adult stem cells are necessary for tissue homeostasis, and in most cases are localized...