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Keywords: Stem cell activation
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Journal Articles

Aging induces aberrant state transition kinetics in murine muscle stem cells

Jacob C. Kimmel, Ara B. Hwang, Annarita Scaramozza, Wallace F. Marshall, Andrew S. Brack
Journal: Development
Development (2020) 147 (9): dev183855.
https://doi.org/10.1242/dev.183855
Published: 5 May 2020
... velocity, we find that activation kinetics are delayed in aged MuSCs, suggesting that changes in stem cell dynamics may contribute to impaired stem cell function with age. Intriguingly, we also find that stem cell activation appears to be a random walk-like process, with frequent reversals, rather than...
View articletitled, Aging induces aberrant state transition kinetics in murine muscle stem cells
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Includes: Supplementary data
Journal Articles

Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation

Karen M. Osorio, Song Eun Lee, David J. McDermitt, Sanjeev K. Waghmare, Ying V. Zhang, Hyun Nyun Woo, Tudorita Tumbar
Journal: Development
Development (2008) 135 (6): 1059–1068.
https://doi.org/10.1242/dev.012799
Published: 15 March 2008
... in tissue stem cells other than blood. Here, we have investigated the role of Runx1 in mouse hair follicle stem cells by conditional ablation in epithelial cells. Runx1 disruption affects hair follicle stem cell activation, but not their maintenance, proliferation or differentiation potential. Adult mutant...
View articletitled, Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation
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Includes: Supplementary data