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Keywords: Stem cell
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Journal Articles
Journal: Development
Development (2021) 148 (5): dev198663.
Published: 09 March 2021
... Drosophila , however, have begun to reveal new roles of nuclear receptor signaling in peripheral tissues in controlling reproduction. Here, we identified Hormone receptor 4 (Hr4) as an oogenesis regulator required in the ovary and muscles. Global Hr4 knockdown leads to increased germline stem cell (GSC) loss...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev178582.
Published: 22 June 2020
... signaling regulates the initial emergence of medullary thymic epithelial sublineage, implicating Notch in the maintenance of primitive thymic epithelial progenitors and uncovering its cross-interaction with Foxn1. Thymus Thymic epithelial cell Stem cell Progenitor cell Lineage divergence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev173377.
Published: 25 October 2019
... polymerase II-dependent transcriptional processes. We found that the control of flower termination was not as robust as classically pictured. In angiosperms, the floral female organs, called carpels, display determinate growth: their development requires the arrest of stem cell maintenance. In vip3 mutant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev179564.
Published: 12 September 2019
... Migration Primitive streak Stem cell In this work, we use our gastruloids to construct a rudimentary fate map of the human PS. We find that different subpopulations of endoderm or mesoderm emerge depending on BMP, WNT and NODAL levels, and that by comparison with the mouse embryo we can arrange...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev174615.
Published: 28 June 2019
...Ying Mao; Renjun Tu; Yan Huang; Decai Mao; Zhihao Yang; Pik Ki Lau; Jinhui Wang; Jianquan Ni; Yusong Guo; Ting Xie ABSTRACT The niche controls stem cell self-renewal and differentiation in animal tissues. Although the exocyst is known to be important for protein membrane trafficking and secretion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev161885.
Published: 10 May 2019
...Samip R. Bhattarai; Salma Begum; Rachel Popow; Ellen J. Ezratty ABSTRACT Arl/ARF GTPases regulate ciliary trafficking, but their tissue-specific functions are unclear. Here, we demonstrate that ciliary GTPase Arl3 is required for mitotic spindle orientation of mouse basal stem cells during skin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev166074.
Published: 16 April 2019
...Xuyu Qian; Hongjun Song; Guo-li Ming ABSTRACT Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used to...
Journal Articles
Journal: Development
Development (2019) 146 (6): dev172791.
Published: 25 March 2019
...Iain Martyn; Ali H. Brivanlou; Eric D. Siggia ABSTRACT Long-range signaling by morphogens and their inhibitors define embryonic patterning yet quantitative data and models are rare, especially in humans. Here, we use a human embryonic stem cell micropattern system to model formation of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (5): dev151894.
Published: 14 March 2019
... controlling adaptation to stress. In this Review, we summarize our current knowledge of the spatiotemporal control of BR action in plant growth and development, focusing on BR functions in primary root development and growth, in stem cell self-renewal and death, and in plant adaption to environmental stress...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev172148.
Published: 01 February 2019
... Signaling Stem cell Notch is a cell surface receptor that provides Metazoans with an exquisitely simple cell-cell communication device ( Artavanis-Tsakonas et al., 1999 ; Bray, 1998 ; Kopan and Ilagan, 2009 ). Its ectodomain can read information about the state of neighboring cells, as it...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171520.
Published: 01 February 2019
... microbial-induced ROS generation within Drosophila larval stem cell compartments exhibits a distinct spatial distribution. Lactobacilli-induced ROS is strictly excluded from defined midgut compartments that harbor adult midgut progenitor (AMP) cells, forming a functional ‘ROS sheltered zone’ (RSZ). The RSZ...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (24): dev158352.
Published: 10 December 2018
... analysis of REVOLUTA reveals a link between leaf patterning and light-mediated growth responses . Plant J.   72 , 31 - 42 . 10.1111/j.1365-313X.2012.05049.x Burian , A. , Barbier de Reuille , P. and Kuhlemeier , C. ( 2016 ). Patterns of stem cell divisions contribute to plant...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169136.
Published: 05 December 2018
..., and these non-steroidogenic cells serve as potential ALC stem cells. We generated FLC lineage-specific Nr5a1 ( Ad4BP/SF-1 ) gene-disrupted mice and mice lacking the fetal Leydig enhancer (FLE) of the Nr5a1 gene. Phenotypes of these mice support the conclusion that most of the ALCs arise from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev167197.
Published: 25 October 2018
... Pediatric Postnatal growth Regeneration Stem cell Prepuberty is a period of pediatric growth that precedes early adolescence ( Dutta and Sengupta, 2016 ). After weaning and prior to the onset of puberty, with the induction of sex hormones marking the beginning of adolescence, skeletal muscle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev165795.
Published: 01 October 2018
... and nutrient homeostasis. Recently developed human intestinal organoid models include EECs, but their rarity makes it difficult to study their formation and function. Here, we used the EEC-inducing property of the transcription factor NEUROG3 in human pluripotent stem cell-derived human intestinal...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2018) 145 (16): dev163485.
Published: 15 August 2018
... Stem cell Lung disease Lung cancer is the most common cancer worldwide, and end-stage respiratory failure accounts for the third highest cause of mortality due to non-infectious disease (Global status report on noncommunicable diseases 2010, World Health Organization; http://www.who.int/nmh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163386.
Published: 08 August 2018
... for HDAC activity initiates in naïve blastula cells; HDAC inhibition causes loss of pluripotency gene expression and blocks the ability of blastula stem cells to contribute to lineages of the three embryonic germ layers. We find that pluripotent naïve blastula cells and neural crest cells are both...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev157149.
Published: 18 July 2018
... progenitor populations during organogenesis. The mammalian kidney maintains a population of self-renewing stem cells that differentiate to give rise to thousands of nephrons, which are the functional units that carry out filtration to maintain physiological homeostasis. The polycomb repressive complex 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev143420.
Published: 13 April 2018
...Hongbo Zhang; Keir J. Menzies; Johan Auwerx ABSTRACT The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the...
Journal Articles
Journal: Development
Development (2018) 145 (7): dev150441.
Published: 28 March 2018
...Phong Dang Nguyen; Peter David Currie Stem cells are undifferentiated cells that play crucial roles during development, growth and regeneration. Traditionally, these cells have been primarily characterised by histology, cell sorting, cell culture and ex vivo methods. However, as stem cells interact...