...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Riccardo M. Betto; Nicola Facchinello; Annachiara Tesoriere; Natascia Tiso; Graziano Martello; Francesco Argenton ABSTRACT The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem...

...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Nicola Facchinello; Andrea Vettori; Giorgio Licciardello; Natascia Tiso; Francesco Argenton ABSTRACT The transcription factor Stat3 is required for proliferation and pluripotency of embryonic stem cells; we have prepared...

... is determined by environmental factors. These experiments revealed that embryonic lung epithelial identity is extrinsically determined. We show that both glucocorticoid and STAT3 signalling can control the timing of alveolar initiation, but that neither pathway is absolutely required for alveolar fate...

...Kento Onishi; Peter W. Zandstra Leukemia inhibitory factor (LIF) is a member of the interleukin-6 (IL-6) cytokine family. All members of this family activate signal transducer and activator of transcription 3 (STAT3), a transcription factor that influences stem and progenitor cell identity...

... the activation of the intracellular signaling pathways downstream of LIF in ESCs with different genetic backgrounds. We found that the JAK-Stat3 pathway was dominantly activated in ESCs derived from ‘permissive’ mouse strains (129Sv and C57BL6), whereas the MAP kinase pathway was hyperactivated in ESCs from ‘non...

... downregulate components of the Lif signaling pathway, such as Lifr, Gp130 and activated Stat3, as well as pluripotency-associated markers. From these observations, we hypothesize that the changes in gene expression accompanying the loss of pluripotency are a direct consequence of dysfunctional cell adhesion...

... to execute involution occurred in the presence of milk stasis and STAT3 activation, indicating that neither is sufficient to initiate involution in the absence of CSF1R + macrophages. Injection of wild-type bone marrow-derived macrophages (BMDMs) or M2-differentiated macrophages into macrophage-depleted...

...Takeshi Yoshimatsu; Daichi Kawaguchi; Koji Oishi; Kiyoshi Takeda; Shizuo Akira; Norihisa Masuyama; Yukiko Gotoh The transcription factor STAT3 promotes astrocytic differentiation of neural precursor cells (NPCs) during postnatal development of the mouse neocortex, but little has been known...

...Ekaterini A. Kritikou; Andrew Sharkey; Kathrine Abell; Paul J. Came; Elizabeth Anderson; Richard W. E. Clarkson; Christine J. Watson STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF is the physiological activator of STAT3, because in involuting mammary glands...

..., it was previously shown that milk stasis induces an unknown mammary-derived growth factor that stimulates STAT3 phosphorylation ( Li et al., 1997 ). While it is not known whether the JAK/Stat pathway is directly downstream of TGF β signaling, our finding that mammary glands having overexpressed TGF β 3...