... characterised EC shapes and their dynamic changes. We show that germ cell encapsulation by ECs is a communal phenomenon, whereby EC-EC contacts stabilise an extensive meshwork of protrusions. We further show that Signal Transducer and Activator of Transcription (Stat) and Epidermal Growth Factor Receptor (Egfr...

... of Jak/Stat signaling in ISCs. Crucially, knocking down Jak/Stat or Spitz/Egfr signaling suppresses Apc1 -dependent ISC hyperproliferation. In summary, our results uncover a novel non-cell-autonomous interplay between Wnt/Myc, Egfr and Jak/Stat signaling in the regulation of intestinal hyperproliferation...

... localisation of STATc. Treatment of cells with DIF-1 or exposure to hyper-osmotic stress induces a decrease in biochemically assayable PTP3 activity and both agents also induce serine-threonine phosphorylation of PTP3. These observations suggest a novel mode of STAT activation, whereby serine-threonine...

.... In the Drosophila eye imaginal disc, Wingless (Wg) signaling defines the region that gives rise to head tissue. JAK/STAT signaling was thought to regulate growth of the eye disc but not pattern formation. However, we show that the JAK/STAT pathway plays an important role in patterning the eye disc:it promotes...

...Debra L. Silver; Erika R. Geisbrecht; Denise J. Montell The evolutionarily conserved JAK/STAT signaling pathway is essential for the proliferation, survival and differentiation of many cells including cancer cells. Recent studies have implicated this transcriptional pathway in the process of cell...

...Willis X. Li; Herve Agaisse; Bernard Mathey-Prevot; Norbert Perrimon Malignant transformation frequently involves aberrant signaling from receptor tyrosine kinases (RTKs). These receptors commonly activate Ras/Raf/MEK/MAPK signaling but when overactivated can also induce the JAK/STAT pathway...

...Dirk Dormann; Tomoaki Abe; Cornelis J. Weijer; Jeffrey Williams ABSTRACT Dd-STATa, the Dictyostelium STAT (signal transducer and activator of transcription) protein, is selectively localised in the nuclei of a small subset of prestalk cells located in the slug tip. Injection of cAMP...

..., functions primarily through the JAK/Stat signaling pathway by phosphorylation and nuclear localization of Stat3. Although Stat3 signaling is described as rapid and transient in branching renal cells ( Boccaccio et al., 1998 ), the constitutive expression of LIF in induced explants, as indicated in RT-PCR...

...Sudhasri Mohanty; Keith A. Jermyn; Anne Early; Takefumi Kawata; Laurence Aubry; Adriano Ceccarelli; Pauline Schaap; Jeffrey G. Williams; Richard A. Firtel Dd-STATa is a structural and functional homologue of the metazoan STAT (Signal Transducer and Activator of Transcription) proteins. We show...