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Keywords: Stanniocalcin
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Journal Articles
Stefani Gjorcheska, Sandhya Paudel, Sarah McLeod, David Paulding, Louisa Snape, Karen Camargo Sosa, Cunming Duan, Robert Kelsh, Lindsey Barske
Journal:
Development
Development (2025) 152 (2): dev204357.
Published: 20 January 2025
... that systemically regulates ionocyte numbers. RNA sequencing revealed significantly elevated stanniocalcin (Stc1a), an anti-hypercalcemic hormone, in sox10 mutants. Stc1a inhibits calcium uptake in fish by repressing trpv6 expression and Trpv6 + ionocyte proliferation. Epistasis assays confirm excess Stc1a...
Includes: Supplementary data