... the initial expression of the drivers of Sertoli cell fate, SRY and/or SOX9, in the central domain, followed by paracrine expansion to the poles. However, we show here that the earliest cells expressing SRY and SOX9 are widely distributed across the gonad. In addition, Sertoli cell fate does not spread among...

... was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry . This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what...

...Christian Larney; Timothy L. Bailey; Peter Koopman Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y ( Sry ). Reduced or delayed Sry expression impairs testis...

...Kenichi Kashimada; Peter Koopman SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which...

...Ryuji Hiramatsu; Kyoko Harikae; Naoki Tsunekawa; Masamichi Kurohmaru; Isao Matsuo; Yoshiakira Kanai In mouse embryogenesis, Sry is transiently activated in a center-to-pole wavelike manner along the anteroposterior (AP) axis of developing XY gonads. However, the mechanism and significance...

...Ryuji Hiramatsu; Shogo Matoba; Masami Kanai-Azuma; Naoki Tsunekawa; Yuko Katoh-Fukui; Masamichi Kurohmaru; Ken-ichirou Morohashi; Dagmar Wilhelm; Peter Koopman; Yoshiakira Kanai In mammals, the Y-linked sex-determining gene Sry cell-autonomously promotes Sertoli cell differentiation from...

... ). Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development 126 , 457 -467. Herbarth, B., Pingault, V., Bondurand, N., Kuhlbrodt, K.,Hermans-Borgmeyer, I., Puliti, A., Lemort, N., Goossens, M. and Wegner, M. ( 1998 ). Mutation of the Sry-related Sox10 gene...

...-mail: [email protected] ) 2 7 2007 © 2007. 2007 Sry High mobility group Glia Oligodendrocyte Neural crest Schwann cell Satellite glia Sox10, like other transcription factors of the Sox family, is an important regulator of embryonic development ( Hong and Saint...

...Mayuko Ishii; Tsuyoshi Tachiwana; Anshin Hoshino; Naoki Tsunekawa; Ryuji Hiramatsu; Shogo Matoba; Masami Kanai-Azuma; Hayato Kawakami; Masamichi Kurohmaru; Yoshiakira Kanai The sex-determining region of Chr Y (Sry) gene is sufficient to induce testis formation and the subsequent male development...

... and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 1 6 2006 © 2006. 2006 Sry High-mobility-group...

... that Dax1 plays an early essential role in fetal testis development. We hypothesize that upregulation of Sox9 expression in precursor somatic cells, a process required for their differentiation as Sertoli cells, depends on the coordinated expression of Dax1 , Sry and another gene, Tda1 . Our conclusion...

... is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry : (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization...

...-erlangen.de ) 9 2 2004 © 2004. 2004 Sry High-mobility-group Sox10 Redundancy Gene dosage Oligodendrocyte Transcription factors of the Sox protein family represent important developmental regulators in vertebrates as well as invertebrates( Wegner, 1999 ). With sequencing...

...Humphrey H.-C. Yao; Leo DiNapoli; Blanche Capel The developmental fate of primordial germ cells in the mammalian gonad depends on their environment. In the XY gonad, Sry induces a cascade of molecular and cellular events leading to the organization of testis cords. Germ cells are sequestered inside...

...Sergei G. Tevosian; Kenneth H. Albrecht; John D. Crispino; Yuko Fujiwara; Eva M. Eicher; Stuart H. Orkin In mammals, Sry expression in the bipotential, undifferentiated gonad directs the support cell precursors to differentiate as Sertoli cells, thus initiating the testis differentiation pathway...

...Jennifer Schmahl; Eva M. Eicher; Linda L. Washburn; Blanche Capel ABSTRACT Sry is the only gene on the Y chromosome that is required for testis formation in mammals. One of the earliest morphological changes that occurs as a result of Sry expression is a size increase of the rudimentary XY gonad...

...Christopher Tilmann; Blanche Capel ABSTRACT In mammals a single gene on the Y chromosome, Sry , controls testis formation. One of the earliest effects of Sry expression is the induction of somatic cell migration from the mesonephros into the XY gonad. Here we show that mesonephric cells...

...-acid DNA-binding domain known as the HMG box. Partial clones for the first three Sox genes (a1-a3) were isolated by homology to the HMG box of the testis-determining gene Sry and are now termed Sox-1, Sox-2 and Sox-3. Sox-3 is highly conserved amongst mammalian species and is located on the X...

...Adam Hacker; Blanche Capel; Peter Goodfellow; Robin Lovell-Badge ABSTRACT In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely to be efficiently translated...

... the Y chromosome gene SRY (sex determining region Y gene), shown to be the testis determining gene. These results suggest that XX intersex moles may have arisen from a mutation of a gene located downstream from SRY/TDY in the testis determining pathway. 13 05 1993 © 1993 by Company...