... in development could be largely replaced by expression of any TGF-α ligand, including spitz (spi), in the endogenous vn pattern. vn mutants die as white undifferentiated pupae, but the rescued individuals showed global differentiation of adult body parts. Spi is more potent than Vn, and the best morphological...

... in the nucleus. In contrast, the mechanisms by which autocrine effects are regulated in the ligand-producing cell are unclear. In the Drosophila eye, Egfr signaling, induced by the Spitz ligand, is required for differentiation of all photoreceptors except for R8, the primary source of Spitz. R8 differentiation...

... Patterning Ommatidial rotation Adhesion Epidermal growth factor receptor spitz keren scabrous nemo roulette argos Development of complex organisms requires tissues to undergo significant morphogenesis and remodelling. One example of such a process occurs in the Drosophila eye...

... this response specificity. We have analysed the specification of bract cells in Drosophila legs. We observed that mechanosensory bristles induced bract fate in neighbouring epidermal cells, and that the RAS/MAPK pathway mediated this induction. We have identified Spitz and EGFr as the ligand and the receptor...

... 1999 by Company of Biologists 1999 zfh-1 even-skipped numb Notch spitz EGF receptor Lineage Cell fate Zinc finger Homeodomain Heart Pericardial cell Myocardium Drosophila Mesoderm Cardiogenesis Myogenesis The Drosophila heart is linear and thus very different...

..., Egfr encodes the Drosophila EGF-Receptor, spitz (spi) and vein (vn) encode EGF-related ligands, and rhomboid (rho) and Star (S) encode membrane proteins. In this study, we show that rho -mediated hyperactivation of the EGFR/MAPK pathway is required for vein formation throughout late larval and early...

... Wing D/V boundary EGFR signaling Notch signaling spitz vestigial The Drosophila wing develops as an outgrowth of the pouch region of the larval wing imaginal disc (Fig. 1A). The pouch is compartmentalized by Anterior-Posterior (A/P) and Dorso-Ventral (D/V) boundaries (reviewed...

... decisions in the Drosophila eye . Cell 69 , 963 – 975 . Freeman , M. (1994a). The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor . Mech. Dev . 48 , 25 – 33 . Freeman , M. (1994b). Missexpression...

... the Ras1-MAP kinase pathway. Localized activation of DER is accomplished by restricted processing of the activating ligand, Spitz. Processing is confined to the cell row posterior to the Engrailed domain by the restricted expression of Rhomboid. These cells also express the inhibitory ligand Argos, which...

... of function in genes of the spitz group or Drosophila EGF receptor (DER) pathway. Argos, a secreted molecule with an atypical EGF motif, is postulated to function as a DER antagonist. In this work, we assess the role of argos in the determination of midline glia cell number. Although all midline glia express...

... by the specific signal that induces it, but is instead a function of the state of the cell when it receives the signal. DER signalling is activated by the ligand, Spitz, and inhibited by the secreted protein, Argos. Spitz is initially produced by the central cells in the ommatidium and diffuses over a small...

... homolog Spitz in Drosophila . It has been shown that Spitz and EGFR act in the development of the Drosophila central nervous system and compound eye. Here we show that spitz function is required in developing ommatidia for the first cell recruitment step, and that Spitz pro-protein is expressed...

...Myriam Golembo; Erez Raz; Ben-Zion Shilo ABSTRACT The Drosophila EGF receptor (DER) is activated by secreted Spitz to induce different cell fates in the ventral ectoderm. Processing of the precursor transmembrane Spitz to generate the secreted form was shown to be the limiting event, but the cells...