... inner ear – the vestibular and cochlear sensory epithelia and the spiral ganglion – by measuring electrophysiological properties and gene expression. Lgr5 + progenitor cells from the sensory epithelia gave rise to hair cell-like cells, but not neurons or glial cells. Newly created hair cell-like cells...

..., parvalbumin and Brn3b. Selective loss of TrkC neurons in the spiral ganglion of Brn3a −/− cochlea leads to an innervation defect similar to that of TrkC −/− mice. Most remarkably, our results uncover a novel role for Brn3a in regulating axon pathfinding and target field innervation by spiral and vestibular...