...Clayton J. Becker; Valentina Cigliola; Pierre Gillotay; Ashley Rich; Alessandro De Simone; Yanchao Han; Stefano Di Talia; Kenneth D. Poss ABSTRACT Identification of signaling events that contribute to innate spinal cord regeneration in zebrafish can uncover new targets for modulating injury...

...Antonio Herrera; Anghara Menendez; Andrea Ochoa; Lídia Bardia; Julien Colombelli; Sebastian Pons ABSTRACT Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription activation that confers dorsal identity to neural stem cells, neurogenesis redirects β-catenin...

.... Here, we demonstrate that a restricted pool of progenitors in the mouse spinal cord, expressing the transcription factor Dbx1, produces a subset of astrocytes, in addition to interneurons. Ventral p0-derived astrocytes (vA0 cells) exclusively populate intermediate regions of spinal cord...

...Sarah E. Walker; Keith Z. Sabin; Micah D. Gearhart; Kenta Yamamoto; Karen Echeverri ABSTRACT Axolotls are an important model organism for multiple types of regeneration, including functional spinal cord regeneration. Remarkably, axolotls can repair their spinal cord after a small lesion injury...

...Teresa Rayon; Rory J. Maizels; Christopher Barrington; James Briscoe ABSTRACT The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising molecularly distinct...

... patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. Here, we show that members of the HoxD family of transcription...

... remains unclear. Here, we studied HOX clock pacing in human pluripotent stem cell-derived axial progenitors differentiating into diverse spinal cord motor neuron subtypes. We show that the progressive activation of caudal HOX genes is controlled by a dynamic increase in FGF signaling. Blocking the FGF...

... to neurodegeneration. Thus, it is a crucial parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine/disease modelling applications. However, the in vitro generation of posterior MNs corresponding to the thoracic/lumbosacral spinal cord has been...

...Vasiliki Tsata; Volker Kroehne; Daniel Wehner; Fabian Rost; Christian Lange; Cornelia Hoppe; Thomas Kurth; Susanne Reinhardt; Andreas Petzold; Andreas Dahl; Markus Loeffler; Michell M. Reimer; Michael Brand ABSTRACT Spinal cord injury (SCI) results in loss of neurons, oligodendrocytes and myelin...

... of mammalian posterior Hox TFs to bind to previously inaccessible chromatin is the predominant force driving their patterning diversification. Hox Binding Chromatin Spinal cord Stem cell differentiation Patterning Hox genes encode a highly conserved transcription factor (TF) family...

...Kayt Scott; Rebecca O'Rourke; Austin Gillen; Bruce Appel ABSTRACT Spinal cord pMN progenitors sequentially produce motor neurons and oligodendrocyte precursor cells (OPCs). Some OPCs differentiate rapidly as myelinating oligodendrocytes, whereas others remain into adulthood. How pMN progenitors...

... of the molecular mechanisms of regeneration. Heart Regeneration Spinal cord Tail Xenopus Appendage Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/M011208/1 British Heart Foundation 10.13039/501100000274 RM/17/2/33380 The goal...

... that are responsible for neuronal specification and provide a compendium of gene expression for classifying spinal cord cell types that will support future studies of neural tube development, function and disease. * These authors contributed equally to this work ‡ Authors for correspondence ( james.briscoe...

...Vanessa Gerber; Lixin Yang; Masanari Takamiya; Vanessa Ribes; Victor Gourain; Ravindra Peravali; Johannes Stegmaier; Ralf Mikut; Markus Reischl; Marco Ferg; Sepand Rastegar; Uwe Strähle ABSTRACT Specification of neurons in the spinal cord relies on extrinsic and intrinsic signals, which in turn...

..., the effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis...

..., and the emergence and elaboration of patterning mechanisms to organise cells in time and space. Vertebrates also generally have many more cells in their central nervous systems than invertebrates, and an increase in neural cell number may have contributed to the sophisticated anatomy of the brain and spinal cord...

... axon growth and adult regeneration failure, exploring the hypothesis that adult central neurons can regenerate by recapitulating development. Axon regeneration Central nervous system Development Spinal cord Spinal cord injury Neurons transmit signals to their targets through...

...Heejin Nam; Seunghee Lee During spinal cord development, motor neuron (MN) axons exit the spinal cord ventrally, although the molecular basis for this process remains poorly understood. STAM1 and HRS form a complex involved with endosomal targeting of cargo proteins, including the chemokine...

...-dependent LIM complexes, which govern the development of spinal motor neurons and V2a interneurons, activate the transcription in the embryonic spinal cord. We found that single-stranded DNA-binding proteins are recruited to these LIM complexes via NLI, and enhance their transcriptional activation potential...

... the timing of differentiation contributes to neuronal diversity in the developing spinal cord is still a pending question. In this study, we show that cerebrospinal fluid-contacting neurons (CSF-cNs), an anatomically discrete cell type of the ependymal area, originate from surprisingly late neurogenic events...