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Keywords: Spinal cord
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Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (15): dev199711.
Published: 05 August 2021
...Teresa Rayon; Rory J. Maizels; Christopher Barrington; James Briscoe ABSTRACT The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are carried out by neural circuits comprising molecularly distinct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev191122.
Published: 15 June 2021
... patterns of proprioceptive sensory neurons in the spinal cord, and the ligand-receptor molecules involved in cell-to-cell recognition. However, with few exceptions, the transcription factors engaged in this process are poorly characterized. Here, we show that members of the HoxD family of transcription...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (6): dev194514.
Published: 29 March 2021
... remains unclear. Here, we studied HOX clock pacing in human pluripotent stem cell-derived axial progenitors differentiating into diverse spinal cord motor neuron subtypes. We show that the progressive activation of caudal HOX genes is controlled by a dynamic increase in FGF signaling. Blocking the FGF...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2021) 148 (6): dev194415.
Published: 23 March 2021
... to neurodegeneration. Thus, it is a crucial parameter in the design of strategies aiming to produce MNs from human pluripotent stem cells (hPSCs) for regenerative medicine/disease modelling applications. However, the in vitro generation of posterior MNs corresponding to the thoracic/lumbosacral spinal cord has been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (24): dev193946.
Published: 16 December 2020
...Vasiliki Tsata; Volker Kroehne; Daniel Wehner; Fabian Rost; Christian Lange; Cornelia Hoppe; Thomas Kurth; Susanne Reinhardt; Andreas Petzold; Andreas Dahl; Markus Loeffler; Michell M. Reimer; Michael Brand ABSTRACT Spinal cord injury (SCI) results in loss of neurons, oligodendrocytes and myelin...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev194761.
Published: 23 November 2020
..., spinal cord neuronal diversity requires Hox gene activity along its rostrocaudal axis ( Sweeney et al., 2018 ; Dasen and Jessell, 2009 ; Dasen et al., 2003 ). The limb-innervating expression program is controlled by central Hox TFs (HOX6 and HOX8) at the brachial spinal cord and by posterior Hox TFs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (16): dev191023.
Published: 27 August 2020
...Kayt Scott; Rebecca O'Rourke; Austin Gillen; Bruce Appel ABSTRACT Spinal cord pMN progenitors sequentially produce motor neurons and oligodendrocyte precursor cells (OPCs). Some OPCs differentiate rapidly as myelinating oligodendrocytes, whereas others remain into adulthood. How pMN progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev180844.
Published: 19 March 2020
... mechanism necessary and sufficient to induce Xenopus tail regeneration . Development   134 , 1323 - 1335 . 10.1242/dev.02812 Allison , D. J. and Ditor , D. S. ( 2015 ). Immune dysfunction and chronic inflammation following spinal cord injury . Spinal Cord   53 , 14 - 18 . 10.1038/sc...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173807.
Published: 27 March 2019
... that are responsible for neuronal specification and provide a compendium of gene expression for classifying spinal cord cell types that will support future studies of neural tube development, function and disease. * These authors contributed equally to this work ‡ Authors for correspondence ( james.briscoe...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev172510.
Published: 20 February 2019
...Vanessa Gerber; Lixin Yang; Masanari Takamiya; Vanessa Ribes; Victor Gourain; Ravindra Peravali; Johannes Stegmaier; Ralf Mikut; Markus Reischl; Marco Ferg; Sepand Rastegar; Uwe Strähle ABSTRACT Specification of neurons in the spinal cord relies on extrinsic and intrinsic signals, which in turn...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev159343.
Published: 16 January 2019
..., the effects of morphological changes on intercellular signaling remain to be fully elucidated. In this study, we examined the effect of morphological changes in Wnt-producing cells on intercellular signaling in the spinal cord. After mid-gestation, roof-plate cells stretched along the dorsoventral axis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev166595.
Published: 09 January 2019
..., and the emergence and elaboration of patterning mechanisms to organise cells in time and space. Vertebrates also generally have many more cells in their central nervous systems than invertebrates, and an increase in neural cell number may have contributed to the sophisticated anatomy of the brain and spinal cord...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3417–3429.
Published: 01 October 2017
... axon growth and adult regeneration failure, exploring the hypothesis that adult central neurons can regenerate by recapitulating development. Axon regeneration Central nervous system Development Spinal cord Spinal cord injury Neurons transmit signals to their targets through...
Journal Articles
Journal: Development
Development (2016) 143 (13): 2334–2343.
Published: 01 July 2016
...Heejin Nam; Seunghee Lee During spinal cord development, motor neuron (MN) axons exit the spinal cord ventrally, although the molecular basis for this process remains poorly understood. STAM1 and HRS form a complex involved with endosomal targeting of cargo proteins, including the chemokine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1721–1731.
Published: 15 May 2016
...-dependent LIM complexes, which govern the development of spinal motor neurons and V2a interneurons, activate the transcription in the embryonic spinal cord. We found that single-stranded DNA-binding proteins are recruited to these LIM complexes via NLI, and enhance their transcriptional activation potential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 880–891.
Published: 01 March 2016
... the timing of differentiation contributes to neuronal diversity in the developing spinal cord is still a pending question. In this study, we show that cerebrospinal fluid-contacting neurons (CSF-cNs), an anatomically discrete cell type of the ependymal area, originate from surprisingly late neurogenic events...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (19): 3416–3428.
Published: 01 October 2015
... undefined. Here, we show that the transcription factor Prdm12 is selectively expressed in p1 progenitors of the hindbrain and spinal cord in the frog embryo, and that a similar restricted expression profile is observed in the nerve cord of other vertebrates as well as of the cephalochordate amphioxus. Using...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (17): 2864–2875.
Published: 01 September 2015
...Domingos Henrique; Elsa Abranches; Laure Verrier; Kate G. Storey Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (9): 1651–1660.
Published: 01 May 2015
... critical for Shh pathway activation. Cilium Hedgehog signaling Mouse Spinal cord Sufu The Hedgehog (Hh) family of secreted proteins mediates numerous inductive events crucial for the proliferation, differentiation and migration of cells in diverse species ranging from planarian to fruit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 811–816.
Published: 01 March 2015
...Catherina G. Becker; Ruth Diez del Corral The spinal cord constitutes an excellent model system for studying development and regeneration of a functional nervous system, from specification of its precursors to circuit formation. The latest advances in the field of spinal cord development and its...