...% of patients with untreated bilateral cryptorchidism exhibit azoospermia due to defective spermatogenesis in the affected testis. While abnormal spermatogonial stem cell maintenance or differentiation is suggested to cause germ cell degeneration in the cryptorchid testis, underlying molecular mechanisms remain...

...Yang Yang; Yinan Zhou; Gary Wessel; Weihua Hu; Dongdong Xu ABSTRACT Seasonal spermatogenesis in fish is driven by spermatogonial stem cells (SSCs), which undergo a complex cellular process to differentiate into mature sperm. In this study, we characterized spermatogenesis in the large yellow...

... spermatocytes. We further identify that deletion of Rad50 in gonocytes leads to complete loss of spermatogonial stem cells due to genotoxic stress. Taken together, our results reveal the essential role of Rad50 in mammalian germ cell meiosis and mitosis, and provide in vivo views of RAD50 function in meiotic...

.... et al. ( 2021 ). Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis . Cell Rep. Med. 2 , 100395 . 10.1016/j.xcrm.2021.100395 Dreef , H. C. , Van , E. E. and De Rijk , E. P. ( 2007...

... for stem cells. Spermatogonial stem cells (SSCs) are unique among tissue-stem cells because they undergo ROS-dependent self-renewal via NOX1 activation. However, the mechanism by which SSCs are protected from ROS remains unknown. Here, we demonstrate a crucial role for Gln in ROS protection using cultured...

...Hue M. La; Ai-Leen Chan; Julien M. D. Legrand; Fernando J. Rossello; Christina G. Gangemi; Antonella Papa; Qiang Cheng; Eric F. Morand; Robin M. Hobbs ABSTRACT Male fertility is dependent on spermatogonial stem cells (SSCs) that self-renew and produce differentiating germ cells. Growth factors...

...Manju Sharma; Robert E. Braun ABSTRACT In the murine testis, self-renewal of spermatogonial stem cells (SSCs) requires glial cell line-derived neurotrophic factor (GDNF) secreted from neighboring somatic cells. However, it not clear how GDNF promotes self-renewal in vivo or what downstream...

...Dirk G. de Rooij Spermatogonial stem cells (SSCs) are crucial for maintaining spermatogenesis throughout life, and understanding how these cells function has important implications for understanding male infertility. Recently, various populations of cells harbouring stem cell-like properties have...

...Dawn L. Lovelace; Zhen Gao; Kazadi Mutoji; Yuntao Charlie Song; Jianhua Ruan; Brian P. Hermann Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood...

...Virginie Olive; Nicole Wagner; Susan Chan; Philippe Kastner; Christine Vannetti; François Cuzin; Minoo Rassoulzadegan In the adult mammalian testis, spermatogenic differentiation starts from a minute population of spermatogonial stem cells (SSCs). SSCs are generated after birth from the fetal...