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Keywords: Spermatogenesis
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
...Na Liu; Fatimunnisa Qadri; Hauke Busch; Stefanie Huegel; Gabin Sihn; Ilya Chuykin; Enno Hartmann; Michael Bader; Franziska Rother ABSTRACT Spermatogenesis is driven by an ordered series of events, which rely on trafficking of specific proteins between nucleus and cytoplasm. The karyopherin α family...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (17): dev198788.
Published: 09 September 2021
... in Drosophila , Orb2, is a principal player in spermatogenesis. It is required for meiosis and spermatid differentiation. During the later process, orb2 mRNA and protein are localized within the developing spermatid. To evaluate the role of the orb2 mRNA 3′UTR in spermatogenesis, we used the CRISPR/Cas9 system...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (16): dev199686.
Published: 12 August 2021
...Grigor Varuzhanyan; Mark S. Ladinsky; Shun-ichi Yamashita; Manabu Abe; Kenji Sakimura; Tomotake Kanki; David C. Chan ABSTRACT Male germline development involves choreographed changes to mitochondrial number, morphology and organization. Mitochondrial reorganization during spermatogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (8): dev196212.
Published: 26 April 2021
...; Kazuyuki Ohbo ABSTRACT During spermatogenesis, intricate gene expression is coordinately regulated by epigenetic modifiers, which are required for differentiation of spermatogonial stem cells (SSCs) contained among undifferentiated spermatogonia. We have previously found that KMT2B conveys H3K4me3...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (7): dev196295.
Published: 15 April 2021
...Xiaoli Wang; Yujiao Wen; Jin Zhang; Grace Swanson; Shuangshuang Guo; Congcong Cao; Stephen A. Krawetz; Zhibing Zhang; Shuiqiao Yuan ABSTRACT Mitochondria play a crucial role in spermatogenesis and are regulated by several mitochondrial fusion proteins. However, their functional importance...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (5): dev195875.
Published: 05 March 2021
... is identified as an essential factor for C. elegans spermatogenesis, functioning with the kinase SPE-6 to sequester the cytoskeletal element MSP into fibrous bodies. Major sperm protein Intrinsically disordered protein Caenorhabditis elegans Spermatogenesis Cytoskeletal assembly spe-18...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev189811.
Published: 29 November 2020
... Folliculogenesis Spermatogenesis Zebrafish Anti-Müllerian hormone (AMH/Amh), also named Müllerian-inhibiting substance (MIS), is a distant member of the transforming growth factor-β (TGF-β) superfamily ( Josso and di Clemente, 1999 ), and its primary function is to induce Müllerian duct regression...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (22): dev193862.
Published: 27 November 2020
...James Matthew Ragle; Abigail L. Aita; Kayleigh N. Morrison; Raquel Martinez-Mendez; Hannah N. Saeger; Guinevere A. Ashley; Londen C. Johnson; Katherine A. Schubert; Diane C. Shakes; Jordan D. Ward ABSTRACT In sexually reproducing metazoans, spermatogenesis is the process by which uncommitted germ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184655.
Published: 12 April 2020
...Guihua Du; Xinrui Wang; Mengcheng Luo; Weiya Xu; Tao Zhou; Mei Wang; Luping Yu; Lufan Li; Li'e Cai; P. Jeremy Wang; John Zhong Li; Jon M. Oatley; Xin Wu ABSTRACT Continual spermatogenesis relies on the actions of an undifferentiated spermatogonial population that is composed of stem cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
... Germ cells Proliferation Differentiation Spermatogenesis Drosophila Maintenance of a multicellular organism during homeostasis and tissue repair requires active replenishment of depleted or injured cells during aging and regeneration. Adult stem cells fulfill this requirement owing...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183764.
Published: 17 March 2020
... with spermatogenesis arrested at MII. Knockout of Cxxc1 led to a decrease in the H3K4me3 level from the pachytene to the MII stage and caused transcriptional disorder. Many spermatogenesis pathway genes were expressed early leading to abnormal acrosome formation in arrested MII cells. In meiotic prophase, deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev183053.
Published: 18 November 2019
... of Drosophila gametogenesis, spermatocytes undergo robust gene transcription and store many transcripts in the cytoplasm in a repressed state, until translational activation of select mRNAs in later steps of spermatogenesis. Here, we characterize the Drosophila Doublefault (Dbf) protein as a C2H2 zinc-finger...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (21): dev178665.
Published: 04 November 2019
..., including zebrafish, have lost the stra8 gene. While RA still seems important for spermatogenesis in fish, it is not known which stage(s) respond to RA or whether its effects are integrated into the endocrine regulation of spermatogenesis. In zebrafish, RA promoted spermatogonia differentiation, supported...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev174128.
Published: 21 October 2019
... meiosis initiation in mice, and the majority of male germ cells are lost in the meiotic defect of first wave spermatogenesis in Wdr62 mutants. Strikingly, in this study, we found that the initiation of meiosis following spermatogenesis was not affected and the germ cells were gradually repopulated...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (17): dev179275.
Published: 02 September 2019
...Josefa Steinhauer; Benjamin Statman; Jeremy K. Fagan; Jacob Borck; Satya Surabhi; Prathibha Yarikipati; Daniel Edelman; Andreas Jenny ABSTRACT Gamete formation is key to survival of higher organisms. In male animals, spermatogenesis gives rise to interconnected spermatids that differentiate...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (13): dev174292.
Published: 28 June 2019
... with its STRIPAK partner, Connector of kinase to AP-1 ( Cka ), where they negatively regulate the Jun N-terminal kinase (JNK) signalling pathway. Our study reveals a novel role for Strip / Cka in JNK pathway regulation during spermatogenesis within the developing Drosophila testis. Author contributions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173088.
Published: 13 May 2019
...Ellen K. Velte; Bryan A. Niedenberger; Nicholas D. Serra; Anukriti Singh; Lorena Roa-DeLaCruz; Brian P. Hermann; Christopher B. Geyer; Allon Klein; Barbara Treutlein ABSTRACT In the mammalian testis, sustained spermatogenesis relies on spermatogonial stem cells (SSCs); their progeny either remain...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev169342.
Published: 15 April 2019
... attributed. Summary: The Par polarity complex suppresses JNK pathway activity in Drosophila somatic support cells to allow stage-specific germ cell survival. Drosophila Spermatogenesis Cyst cells Par complex JNK Understanding how local interactions between epithelia...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (1): dev170225.
Published: 04 January 2019
...Marius Teletin; Nadège Vernet; Jianshi Yu; Muriel Klopfenstein; Jace W. Jones; Betty Féret; Maureen A. Kane; Norbert B. Ghyselinck; Manuel Mark ABSTRACT In mammals, all- trans retinoic acid (ATRA) is instrumental to spermatogenesis. It is synthesized by two retinaldehyde dehydrogenases (RALDH...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169102.
Published: 30 November 2018
... spermatogenesis, whereas most bivalent genes are mainly not expressed until embryonic development. These data suggest that SSCs are epigenetically primed by Kmt2b in two distinguishable ways for the upregulation of gene expression both during the spermatogenic program and through the male germline into the embryo...
Includes: Supplementary data