... in the lateral ganglionic eminence (LGE). Using conditional deletion, we show that mice lacking the transcription factor genes Sp8 and Sp9 lose virtually all D2 MSNs as a result of reduced neurogenesis in the LGE, whereas D1 MSNs are largely unaffected. SP8 and SP9 together drive expression of the transcription...

... as they are clustered at the midline, resembling other midline structures important for maintaining the bilateral organization of the neural tube. Adhesion Cell movement Midline Pituitary Chick RNA-seq Sp8 Placodes are discrete thickenings of the cranial ectoderm localized in the proximity...

... with the well-known caudal migratory stream (CMS), contribute to populate the neocortex, hippocampus and amygdala. These paths appear in a precise temporal sequence and express a distinct combination of transcription factors, such as SP8, PROX1, COUP-TFI and COUP-TFII. By inactivating COUP-TFI in developing...

... and class II transcription factors play important roles in patterning neural progenitors into domains with clear boundaries. Here, we provide evidence that the zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary through mutually repressive interactions...

...., Waclaw, R. R., Campbell, K.,Potter, S. S. and Scott, W. J., Jr ( 2003b ). Sp8 is crucial for limb outgrowth and neuropore closure. Proc. Natl. Acad. Sci. USA 100 , 12195 -12200. Bell, S. M., Schreiner, C. M., Goetz, J. A., Robbins, D. J. and Scott, W. J. J. ( 2005 ). Shh signaling in limb bud...

...Anke Beermann; Manuel Aranda; Reinhard Schröder Members of the Sp gene family are involved in a variety of developmental processes in both vertebrates and invertebrates. We identified the ortholog of the Drosophila Sp-1 gene in the red flour beetle Tribolium castaneum , termed T-Sp8 because of its...