... to direct arterial endothelial cell-restricted expression in transgenic models. Genetic disruption of SoxF binding sites established a clear requirement for members of this group of transcription factors (SOX7, SOX17 and SOX18) to drive the activity of these enhancers in vivo . Endogenous deletion...

... restricted activation of the Sox gene SoxF ( Sox15 ) by wg represses its own transcription,thus ensuring tight regulation of growth control. rotund , a wing proximodistal patterning gene, excludes SoxF from a thin rim of cells. These cells are thus allowed to express wg and act as the source of mitogenic...