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Keywords: Sox9
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Journal Articles
Journal: Development
Development (2019) 146 (14): dev167882.
Published: 26 July 2019
... bone. Despite their importance, the mechanism by which superstructures are patterned is unknown. Here, we identify components of the genetic program that control the patterning of Sox9 + / Scx + superstructure progenitors in mouse and show that this program includes both global and regional regulatory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (4): dev167452.
Published: 28 February 2019
... bones has been challenging. Here, we compare our previously reported mechanisms of patella development in the mouse with those of two anatomically different sesamoids, namely lateral fabella and digit sesamoids. We show that all three types of sesamoid bones originate from Sox9 + / Scx + progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev165381.
Published: 18 December 2018
...Neta Felsenthal; Sarah Rubin; Tomer Stern; Sharon Krief; Deepanwita Pal; Brian A. Pryce; Ronen Schweitzer; Elazar Zelzer ABSTRACT Tendon-bone attachment sites, called entheses, are essential for musculoskeletal function. They are formed embryonically by Sox9 + progenitors and continue to develop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (15): dev163691.
Published: 09 August 2018
... pigmented epithelium (RPE). Here, we describe a novel regulatory relationship between the RPE transcription factors Pax6 and Sox9 that controls the timing of RPE differentiation and the adjacent choroid maturation. We used a novel machine learning algorithm tool to analyze high resolution imaging of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164004.
Published: 26 July 2018
... Sox9, an important transcription factor of skeletogenesis. We further demonstrate that Erk5 directly phosphorylates and activates Smurf2 (a ubiquitin E3 ligase) at Thr 249 , which promotes the proteasomal degradation of Smad proteins and phosphorylates Smad1 at Ser 206 in the linker region known to...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev164459.
Published: 18 July 2018
...Chia-Feng Liu; Marco Angelozzi; Abdul Haseeb; Véronique Lefebvre ABSTRACT SOX9 controls cell lineage fate and differentiation in major biological processes. It is known as a potent transcriptional activator of differentiation-specific genes, but its earliest targets and its contribution to priming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (12): dev165498.
Published: 26 June 2018
... large family of Forkhead transcription factors integrate diverse signaling outputs to specify distinct cartilages and teeth in the developing zebrafish face. Forkhead Foxc1 Foxf1 Foxf2 Sox9 Cartilage Teeth Bone Pharyngeal arches Craniofacial Zebrafish Development of the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev159244.
Published: 16 March 2018
... impairs chondrocyte proliferation and differentiation/maturation, leading to chondrodysplasia. These defects were linked to suppression of SOX9, a master regulator of chondrogenesis, the expression of which is mediated by TEAD transcription factors. Our data indicate that a MOB1-dependent YAP1/TAZ-TEAD...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (2): dev146829.
Published: 25 January 2018
... the embryonic thyroid gland in mice. Sox9, a key factor in branching organ development, distinguishes Nkx2-1 + cells in the thyroid bud from the progenitors that originally form the thyroid placode in anterior endoderm. As lobes develop the thyroid primordial tissue branches several generations. Sox9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4510–4521.
Published: 15 December 2017
... transcription factor SOX9 locus. SOX9 is an HMG-box transcription factor that plays an essential role in chondrocyte development by directing the expression of chondrocyte-specific genes. Two of these lncRNAs are upregulated during chondrogenic differentiation of mesenchymal stem cells (MSCs). Depletion of one...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (12): 2294–2305.
Published: 15 June 2017
... region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (24): 4608–4619.
Published: 15 December 2016
... SOX9 Chondrogenesis Limb development Progenitor cells Differentiating cartilage elements are specified from a highly proliferative mesodermal progenitor population that is specified early in limb development. After specification, progenitor cells coalesce into condensates, activate Sox9...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 3012–3023.
Published: 15 August 2016
...Xinjun He; Shinsuke Ohba; Hironori Hojo; Andrew P. McMahon An analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif. Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (24): 4340–4350.
Published: 15 December 2015
... the cardiac cushions. The transcription factor SOX9 is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion mesenchyme alters cell proliferation, embryonic survival, and valve formation. Despite this important role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1831–1839.
Published: 15 May 2015
... superficially embedded within the quadriceps tendon. At the cellular level, we show that, similar to bone eminences, the patella is formed secondarily by a distinct pool of Sox9 - and Scx -positive progenitor cells. Finally, we show that TGFβ signaling is necessary for the specification of patella progenitors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (6): 1083–1088.
Published: 15 March 2015
... differentiation and male secondary sex development. XX transgenic fetal gonads showed typical testicular size and vasculature. Key ovarian markers, including Wnt4 and Foxl2 , were repressed. Sertoli cells expressing the hallmark testis-determining gene Sox9 were formed, although they did not assemble into normal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (5): 817–831.
Published: 01 March 2015
... development. Chondrogenesis Chondrocyte hypertrophy Growth plate Sox9 Ihh PTHrP Fgfr3 Funding Work in the Lassar lab is supported by grants from the National Institutes of Health. Work in the Zelzer lab is supported by grants from European Research Council (ERC) and the Minerva...
Journal Articles
Journal: Development
Development (2015) 142 (2): 385–393.
Published: 15 January 2015
... endochondral ossification. As a negative regulator, Sox9 is essentially downregulated in terminally differentiated hypertrophic chondrocytes. However, the underlying mechanism of Sox9 silencing is undefined. Here we show that the zinc finger protein Zbtb20 regulates the terminal differentiation of hypertrophic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (22): 4254–4266.
Published: 15 November 2014
...), each of which can generally specify a particular developmental lineage. We previously established 137 mouse ESC lines, each of which carried a doxycycline-controllable TF. Among them, Sox9 has unique capacity: its forced expression accelerates differentiation of mouse ESCs into cells of all three germ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (20): 3978–3987.
Published: 15 October 2014
... 2014 22 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 NKX3.2 GATA factors SHH SOX9 Chondrogenesis Chicken Mouse The majority of the vertebrate skeleton arises by the process of endochondral ossification, in which each skeletal element is established and...
Includes: Supplementary data