... comprise taste bud precursor cells, which express the secreted factor sonic hedgehog (Shh) and give rise to taste bud cells that differentiate around birth. We showed previously that epithelial activation of β-catenin is the primary inductive signal for taste placode formation, followed by taste papilla...

... provided that the original work is properly attributed. Sonic hedgehog (Shh) Enhancers Long-range regulation Topological domains Sleeping beauty transposon Mouse The regulatory architecture of highly regulated genes such as those involved in controlling developmental processes has been...

... Tissue Res. 314 , 157 -166. Bellusci, S., Furuta, Y., Rush, M. G., Henderson, R., Winnier,G. and Hogan, B. L. (1997a). Involvement of Sonic hedgehog(Shh) in mouse embryonic lung growth and morphogenesis. Development 124 , 53 -63. Bellusci, S., Grindley, J., Emoto, H., Itoh, N. and Hogan, B...

... activity, which is independent of NOTCH signaling. Moreover, elevated HES1 expression promotes progenitor cell proliferation and prevents overproduction of retinal ganglion cells owing to the loss of VEGF or sonic hedgehog (SHH), another signal that suppresses ganglion cell development. Based on previous...

... factor 9 (FGF9) Sonic hedgehog (SHH) Lung development Branching morphogenesis Mesothelium Epithelium Mesenchyme Mouse The embryonic lung develops from three distinct tissue layers: the outer mesothelium, the mesenchyme and the bronchial epithelium. Following formation...

..., 1996). Binding of Shh to Ptc lifts the repression of Smo, leading to activation of the transcription factor Gli, and the transcription of direct target genes of Shh signalling. These include Ptc and Gli themselves (reviewed by Ruiz i Altaba, 1997). The protein Sonic hedgehog (Shh) has been...

... is completed. The extracellular signals involved in activating the myogenic programme in muscle precursor cells in the limb in vivo are not known. We wished to investigate whether Sonic Hedgehog (SHH) expressed in the posterior part of the limb bud could be involved in differentiation of the muscle precursor...