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Keywords: Sonic hedgehog
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Journal Articles
Journal: Development
Development (2023) 150 (13): dev201534.
Published: 7 July 2023
... progenitor state at day 14. By the end of a 56-day differentiation procedure, we obtain functional neurons expressing CGN markers GABA A Rα6 and vGLUT2. We show that sonic hedgehog promotes GABAergic lineage specification and CGN progenitor proliferation. Our work presents a new model with which to study...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (7): dev201464.
Published: 6 April 2023
... and signalling pathways that may play a role in its development. For one of these, the Sonic hedgehog (Shh) pathway, we show that co-receptors Gas1 , Cdon and Boc are highly expressed in the VL and act to enhance the Shh signal from the forming incisor region. In Gas1 mutant mice, expression of Gli1...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (16): dev191023.
Published: 27 August 2020
... regulates the timing of a motor neuron-oligodendrocyte switch and oligodendrocyte lineage cell identity in the zebrafish spinal cord by dampening Shh activity in pMN progenitors. Sonic hedgehog Motor neurons Oligodendrocytes pMN progenitors Spinal cord Zebrafish Oligodendrocytes, one...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev191064.
Published: 17 July 2020
... gene-environment interactions in birth defect etiology limits our ability to identify and eliminate avoidable risks. We present mouse models of sonic hedgehog signaling and craniofacial malformations to illustrate both the importance of and current challenges in resolving gene-environment interactions...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (21): dev188078.
Published: 15 June 2020
...Pengcheng Ma; Tao An; Liang Zhu; Longlong Zhang; Huishan Wang; Biyu Ren; Bin Sun; Xia Zhou; Yan Li; Bingyu Mao; Sally Dunwoodie; John Wallingford ABSTRACT Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule neuron progenitors (CGNPs) and its mis-regulation is linked...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183301.
Published: 3 February 2020
...Sandii Constable; Alyssa B. Long; Katharine A. Floyd; Stéphane Schurmans; Tamara Caspary ABSTRACT Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription factors that play both activator (GliA) and repressor (GliR) roles...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167965.
Published: 22 January 2019
... to specific locations in pharyngeal arch (PA) 1 and 2, to form the malleus-incus and stapes, respectively. It is unclear how migratory NCCs reach their proper destination in the PA and initiate mesenchymal condensation to form specific ossicles. We show that secreted molecules sonic hedgehog (SHH) and bone...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev166033.
Published: 17 December 2018
... climbing or mossy fiber inputs to the cerebellum. Gli3 , a zinc-finger transcription factor in the Sonic hedgehog signaling pathway, is an important regulator of dorsal brain development. We demonstrate that in Gli3 -null mutant mice, disrupted neuronal migratory streams lead to a disorganization...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev154856.
Published: 5 April 2018
.... , Hill , R. and Krumlauf , R. ( 1999 ). Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch . Curr. Biol.   9 , 97 - 100 . 10.1016/S0960-9822(99)80022-0 Theiler , K. ( 1989 ). The House Mouse: Atlas of Embryonic...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 1 April 2017
... output to a narrow distal regenerate zone comprising pObs and adjacent motile basal epidermal cells. This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions atypically to support bone maturation. Using BMS-833923...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (16): 2946–2957.
Published: 15 August 2016
... of Sonic hedgehog gene in regenerating newt limb blastemas recapitulates that in developing limb buds . Proc. Natl. Acad. Sci. USA   94 , 9159 - 9164 . 10.1073/pnas.94.17.9159 Kragl , M. , Knapp , D. , Nacu , E. , Khattak , S. , Maden , M. , Epperlein , H. H. and Tanaka...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2016) 143 (14): 2651–2663.
Published: 15 July 2016
... growth and differentiation. Hypothalamus development Anterior hypothalamus Rx3 Sonic hedgehog Tuberal hypothalamus Zebrafish hypothalamus The hypothalamus is an ancient part of the ventral forebrain. It centrally regulates homeostatic processes that are essential to survival...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (2): 264–275.
Published: 15 January 2016
.... These recombinations led to abnormally large and ectopically positioned ganglia. We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial protein not expressed in the bursa, mediates this effect. Inhibition of Shh signaling, by addition of cyclopamine or a function-blocking antibody, resulted...
Includes: Supplementary data