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Keywords: Sonic hedgehog
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Journal Articles
Journal: Development
Development (2020) 147 (16): dev191023.
Published: 27 August 2020
... identity in the zebrafish spinal cord by dampening Shh activity in pMN progenitors. Sonic hedgehog Motor neurons Oligodendrocytes pMN progenitors Spinal cord Zebrafish Oligodendrocytes, one of the major glial cell types of the central nervous system (CNS) of vertebrate animals, increase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev191064.
Published: 17 July 2020
... gene-environment interactions in birth defect etiology limits our ability to identify and eliminate avoidable risks. We present mouse models of sonic hedgehog signaling and craniofacial malformations to illustrate both the importance of and current challenges in resolving gene-environment interactions...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev188078.
Published: 15 June 2020
...Pengcheng Ma; Tao An; Liang Zhu; Longlong Zhang; Huishan Wang; Biyu Ren; Bin Sun; Xia Zhou; Yan Li; Bingyu Mao; Sally Dunwoodie; John Wallingford ABSTRACT Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule neuron progenitors (CGNPs) and its mis-regulation is linked...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183301.
Published: 03 February 2020
...Sandii Constable; Alyssa B. Long; Katharine A. Floyd; Stéphane Schurmans; Tamara Caspary ABSTRACT Sonic hedgehog (Shh) signal transduction specifies ventral cell fates in the neural tube and is mediated by the Gli transcription factors that play both activator (GliA) and repressor (GliR) roles...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180075.
Published: 12 November 2019
... utilised multiple genetic approaches to investigate local temporospatial requirements for sonic hedgehog (SHH) signalling during tongue development. Mice lacking a Shh cis -enhancer, MFCS4 ( ShhMFCS4/− ), with reduced SHH in dorsal tongue epithelium have perturbed lingual septum tendon formation and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (17): dev176784.
Published: 12 September 2019
...Atsuki Yatsuzuka; Akiko Hori; Minori Kadoya; Mami Matsuo-Takasaki; Toru Kondo; Noriaki Sasai ABSTRACT Dorsal-ventral pattern formation of the neural tube is regulated by temporal and spatial activities of extracellular signalling molecules. Sonic hedgehog (Shh) assigns ventral neural subtypes via...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167965.
Published: 22 January 2019
... specific locations in pharyngeal arch (PA) 1 and 2, to form the malleus-incus and stapes, respectively. It is unclear how migratory NCCs reach their proper destination in the PA and initiate mesenchymal condensation to form specific ossicles. We show that secreted molecules sonic hedgehog (SHH) and bone...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev166033.
Published: 17 December 2018
... climbing or mossy fiber inputs to the cerebellum. Gli3 , a zinc-finger transcription factor in the Sonic hedgehog signaling pathway, is an important regulator of dorsal brain development. We demonstrate that in Gli3 -null mutant mice, disrupted neuronal migratory streams lead to a disorganization of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev154856.
Published: 05 April 2018
... . 10.1242/dev.02480 Sharpe , J. , Lettice , L. , Hecksher-Sørensen , J. , Fox , M. , Hill , R. and Krumlauf , R. ( 1999 ). Identification of sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch . Curr. Biol.   9 , 97 - 100 . 10.1016...
Journal Articles
Journal: Development
Development (2017) 144 (18): 3289–3302.
Published: 15 September 2017
...Gabriela Carreno; John R. Apps; Emily J. Lodge; Leonidas Panousopoulos; Scott Haston; Jose Mario Gonzalez-Meljem; Heidi Hahn; Cynthia L. Andoniadou; Juan Pedro Martinez-Barbera Sonic hedgehog (SHH) is an essential morphogenetic signal that dictates cell fate decisions in several developing organs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (11): 2082–2091.
Published: 01 June 2017
... lip morphogenesis is limited. Here, we show in mice that sonic hedgehog (Shh)-induced proliferation of cranial neural crest cell (cNCC) mesenchyme is required for upper lip closure. Gene expression profiling revealed a subset of Forkhead box (Fox) genes that are regulated by Shh signaling during lip...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1165–1176.
Published: 01 April 2017
... output to a narrow distal regenerate zone comprising pObs and adjacent motile basal epidermal cells. This Hh/Smo activity is driven by epidermal Sonic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions atypically to support bone maturation. Using BMS-833923, a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4027–4037.
Published: 01 November 2016
... and parathyroid organogenesis . Development   139 , 3456 - 3466 . 10.1242/dev.079400 Garg , V. , Yamagishi , C. , Hu , T. , Kathiriya , I. S. , Yamagishi , H. and Srivastava , D. ( 2001 ). Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2946–2957.
Published: 15 August 2016
... different cell sources and in response to different signals. Lizard Cartilage Regeneration Sonic hedgehog Indian hedgehog Bone morphogenetic proteins Growth plate Ossification Calcification Periosteum Blastema Lizards are the closest relatives of mammals that exhibit enhanced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2651–2663.
Published: 15 July 2016
.... ( 2012 ). Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions . Neural Dev.   20 , 7-4 . 10.1186/1749-8104-7-4 Amat , P. , Amat-Peral , G. , Pastor , F. E. , Blazquez , J. L. , Pelaez , B. , Alvarez-Morujo , A. , Toranzo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1313–1317.
Published: 15 April 2016
... transformation of gill arches. Tetrapod limbs are patterned by a sonic hedgehog ( Shh )-expressing signalling centre known as the zone of polarising activity, which establishes the anteroposterior axis of the limb bud and maintains proliferative expansion of limb endoskeletal progenitors. Here, we use loss-of...
Journal Articles
Journal: Development
Development (2016) 143 (2): 264–275.
Published: 15 January 2016
... recombinations led to abnormally large and ectopically positioned ganglia. We hypothesized that sonic hedgehog (Shh), a secreted intestinal epithelial protein not expressed in the bursa, mediates this effect. Inhibition of Shh signaling, by addition of cyclopamine or a function-blocking antibody, resulted in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 3996–4009.
Published: 01 December 2015
... Sonic Hedgehog signaling gradient in the vertebrate neural tube . Cell   148 , 273 - 284 . 10.1016/j.cell.2011.10.047 Barolo , S. ( 2012 ). Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy . Bioessays   34 , 135 - 141...
Journal Articles
Journal: Development
Development (2015) 142 (22): 3821–3832.
Published: 15 November 2015
...Pamela S. Ellis; Sarah Burbridge; Sandrine Soubes; Kyoji Ohyama; Nadav Ben-Haim; Canhe Chen; Kim Dale; Michael M. Shen; Daniel Constam; Marysia Placzek The secreted glycoprotein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in induction and patterning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3620–3629.
Published: 01 November 2015
... mechanisms governing taste cell formation and turnover. Taste buds Gustatory system Sonic hedgehog Wnt/β-catenin Cell lineage Molecular genetics Taste dysfunction Dysgeusia Ageusia Chemotherapy Stem cells Lingual organoids Gustation, or the sense of taste, allows us to distinguish...