.... Oscillations Notch signalling Hes1 Somitogenesis Neuromesodermal progenitors Neural tube KWF Kankerbestrijding http://dx.doi.org/10.13039/501100004622 13661 European Research Council http://dx.doi.org/10.13039/100010663 850554 National Science Foundation http...

... http://dx.doi.org/10.13039/501100001665 European Molecular Biology Laboratory http://dx.doi.org/10.13039/100013060 Morphogenesis Mechanobiology Self-organisation Embryogenesis Organoids Somitogenesis Neural tube Stem cells Gastruloids Stembryogenesis Summary...

... Morphogenesis Mechanics Somitogenesis Notochord Vacuolation Wellcome Trust http://dx.doi.org/10.13039/100010269 Royal Society http://dx.doi.org/10.13039/501100000288 109408/Z/15/Z Elongation of the embryo anterior-posterior (AP) axis requires the physical deformation...

... and is, therefore, an obligatory factor in mesodermal competence and/or maintenance. Adhesion Mesoderm RARγ Retinoic acid signaling Somitogenesis Xenopus National Science Foundation 10.13039/100000001 IOS-0719576 IOS-1147236 A.P. Giannini Foundation 10.13039/100002112...

...Amanda Janesick; Weiyi Tang; Tuyen T. L. Nguyen; Bruce Blumberg During vertebrate somitogenesis, retinoic acid is known to establish the position of the determination wavefront, controlling where new somites are permitted to form along the anteroposterior body axis. Less is understood about how RAR...

... ). Wnt3a plays a major role in the segmentation clock controlling somitogenesis . Dev. Cell   4 , 395 - 406 . 10.1016/S1534-5807(03)00055-8 Barnes , G. L. , Alexander , P. G. , Hsu , C. W. , Mariani , B. D. and Tuan , R. S. ( 1997 ). Cloning and characterization of chicken...

... by using tbx6:ggff driver ( Fig. 5 M-P). Thus, Mesp genes are necessary and sufficient to establish rostral identity in the zebrafish somite, as in mouse somitogenesis. On the other hand, previous studies suggested that pcdh8 ( papc ) is also involved in the morphogenesis of somite boundaries...

...Dustin R. Williams; Emily T. Shifley; Kara M. Braunreiter; Susan E. Cole Vertebrate somitogenesis is regulated by a segmentation clock. Clock-linked genes exhibit cyclic expression, with a periodicity matching the rate of somite production. In mice, lunatic fringe ( Lfng ) expression oscillates...

... Spadetail Tbx16 Somitogenesis Vertebrates form an anterior-posterior axis through a process called posterior growth, in which a population of undifferentiated cells resides at the most posterior end of the embryo and gradually contributes cells to the trunk and tail during the somite-forming...

...Robert A. Bone; Charlotte S. L. Bailey; Guy Wiedermann; Zoltan Ferjentsik; Paul L. Appleton; Philip J. Murray; Miguel Maroto; J. Kim Dale During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator...

... 4 6 2014 © 2014. Published by The Company of Biologists Ltd 2014 Body axis extension Somitogenesis Neurogenesis Ligand-induced repression Retinoic acid Raldh2 Fgf8 PRC2 RERE We investigated whether RA restriction of caudal Fgf8 expression is mediated by direct...

... modulator Fgf signaling during zebrafish somitogenesis . Dev. Biol. 336 , 232 – 245 . Matsui T. , Raya A. , Kawakami Y. , Callol-Massot C. , Capdevila J. , Rodríguez-Esteban C. , Izpisúa Belmonte J. C. ( 2005 ). Noncanonical Wnt signaling regulates midline...

... from anterior to posterior, and the anterior somites form in a more rapid cycle than the posterior somites. However, how this anteroposterior (AP) difference in somitogenesis is generated and how it contributes to the vertebrate body plan remain unclear. Here, we show that the AP difference...

... interests. 26 8 2012 © 2012. Published by The Company of Biologists Ltd 2012 Tribolium Arthropods Blastoderm Insects Segmentation clock Somitogenesis Early in embryogenesis, the anterior-posterior (AP) axis of an arthropod embryo is established as a series of body...

... cells. During post-implantation development, the precise timing and mechanism of the loss of pluripotency is unknown. Here, we show that in the mouse, pluripotency is extinguished at the onset of somitogenesis, coincident with reduced expression and chromatin accessibility of Oct4 and Nanog regulatory...

... remains unclear. In combination, these results indicate that cyclic genes are the transcriptionally oscillating component of a larger molecular segmentation clock. Whenever cyclic traveling wave patterns are disrupted, normal somitogenesis is also disrupted. Thus, these phenotypes are consistent...

... Somitogenesis Segmentation Evolution Cyclic genes Segmentation clock Microarray Chicken Zebrafish Mouse Notch Wnt FGF The periodic organization of the vertebrate body, which is most visible in the vertebrae, is established during embryogenesis. In vertebrates, a complex signaling pulse from...

... the threshold level. ( B ) Depiction of the genetic cascade involved in the regulation of Notch signaling during somitogenesis incorporating present and previous data. Mesp2 has three independent functions leading to (1) the induction of Lfng that represses the production of cleaved Notch1 ( Morimoto et al...

... of beta-catenin with the transcription factor LEF-1 . Nature 382 , 638 - 642 . Biris K. K. , Dunty W. C. Jr , Yamaguchi T. P. ( 2007 ). Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis . Dev. Dyn. 236 , 3167 - 3172 . Brady G...

... of Med12 hypomorphic mutants that have a drastic reduction in Med12 protein levels. These mutants fail to develop beyond embryonic day 10 and have severe defects in neural tube closure, axis elongation, somitogenesis and heart formation. We show that in Med12 hypomorphic embryos, the Wnt/planar cell...