... in the development of the paraxial mesoderm tissue. Analysis of gene expression and SALL4 binding suggests that Sall4 directly or indirectly regulates genes involved in presomitic mesoderm differentiation, somite formation and somite differentiation. Furthermore, ATAC-seq in TCre ; Sall4 mutant posterior trunk...

... Hypothalamus Chick embryo Somites Wing bud Wellcome Trust http://dx.doi.org/10.13039/100010269 212247/Z/18/Z 202756/Z/16/Z Engineering and Physical Sciences Research Council http://dx.doi.org/10.13039/501100000266 Developmental biology studies rely on the accurate staging...

.... This Review considers how symmetries and asymmetries form alongside each other within the embryo, and how they are then maintained during growth. I describe how asymmetric signals are generated in the embryo. Using the limbs and somites as major examples, I then address mechanisms for protecting symmetrically...

...Cristian Soza-Ried; Emre Öztürk; David Ish-Horowicz; Julian Lewis Formation of somites, the rudiments of vertebrate body segments, is an oscillatory process governed by a gene-expression oscillator, the segmentation clock. This operates in each cell of the presomitic mesoderm (PSM...

..., CNRS URA 2578,Pasteur Institute, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France 24 11 2008 © 2009. 2009 Retinoids Gastrulation Neurogenesis Spinal cord Somites Sonic hedgehog Gli Fibroblast growth factor Mouse In the vertebrate embryo, the trunk structures (spinal...

... within the primitive streak, resulting in a lateral expansion of somitic mesoderm to form multiple columns. Inhibition of FGF signaling restores the normal timing of recruitment of prospective paraxial mesoderm and partially rescues the development of somites. This suggests that BMP and FGF signaling...

... pectoral fin induction in the aldh1a2/neckless mutant with exogenous RA and by blocking RA signaling in wild-type embryos, we find that RA acts as a permissive signal that is required during the six- to eight-somite stages for pectoral fin induction. Cell-transplantation experiments show that RA production...

... to the formation of five pairs of mammary placodes in the surface ectoderm of the mouse embryo. We have previously shown that fibroblast growth factor 10(FGF10) is required for the formation of mammary placodes 1, 2, 3 and 5. Here,we have found that Fgf10 is expressed only in the somites underlying placodes 2...

...Andrea Pasini; Yun-Jin Jiang; David G. Wilkinson Alterations of the Delta/Notch signalling pathway cause multiple morphogenetic abnormalities in somitogenesis, including defects in intersomitic boundary formation and failure in maintenance of somite regularity. Notch signalling has been implicated...

...Angeleen Fleming; Roger Keynes; David Tannahill The vertebrates are defined by their segmented vertebral column, and vertebral periodicity is thought to originate from embryonic segments, the somites. According to the widely accepted `resegmentation' model, a single vertebra forms from...

..., MiP and CaP, occupy distinct locations within the ventral neural tube relative to overlying somites, express different genes and innervate different muscle territories. In all vertebrates examined so far, paraxial mesoderm-derived signals specify distinct motoneuron subpopulations in specific...

... the rostrocaudal axis at various developmental stages, we have found that the capacity of rhombomeres to generate somatic motoneurones is labile at the neural plate stage but becomes fixed just after neural tube closure, at stage 10-11. Grafting of somites or retinoic acid-loaded beads beneath the rostral...

... by examining chicken somite segmentation as a model system. By transplanting a small group of cells taken from a presumptive border into a non-segmentation site, we have found a novel inductive event where posteriorly juxtaposed cells to the next-forming border instruct the anterior cells to become separated...

...Roy C. Mootoosamy; Susanne Dietrich Most head muscles arise from the pre-otic axial and paraxial head mesoderm. This tissue does not form somites, yet expresses the somitic markers Lbx1 , Pax7 and Paraxis in a regionalised fashion. The domain set aside by these markers provides the lateral rectus...

...Ahmed Mansouri; Patrick Pla; Lionel Larue; Peter Gruss Pax3 is a member of the paired-box-containing transcription factors. It is expressed in the developing somites, dorsal spinal cord, mesencephalon and neural crest derivatives. Several loss-of-function mutations are correlated with the Splotch...

...Julie L. Nowicki; Ann C. Burke ABSTRACT The successful organization of the vertebrate body requires that local information in the embryo be translated into a functional, global pattern. Somite cells form the bulk of the musculoskeletal system. Heterotopic transplants of segmental plate along...

.... The vertebrate homologues of Drosophila Delta are expressed in a dynamic, segmental pattern within the presomitic mesoderm, and alterations in the function of these genes leads to a perturbed pattern of somite segmentation. In this study we have characterised Thylacine 1 which encodes a basic helix-loop-helix...

... on an earlier stage (HH13). Using the quail-chick chimera system, we first show that the presumptive wing mesoderm occupies the medial half of the somatopleure at the level of somites 15-20. The corresponding ectodermal area, however, will only give rise to the apical ectodermal ridge. The rest of the limb bud...

...Wui-Chuong Jen; Daniel Wettstein; David Turner; Ajay Chitnis; Chris Kintner ABSTRACT Segmentation of the vertebrate embryo begins when the paraxial mesoderm is subdivided into somites, through a process that remains poorly understood. To study this process, we have characterized X-Delta-2 , which...

... development, we have analyzed their expression in mouse embryos from day 7.5 of gestation by wholemount in situ hybridization. Met expression is first detected in the ventral portion of somites at day 9.25 of gestation (22 somite embryo) at the level of fore limb buds. As somites mature, met expression...