... mutants bias developing cortical interneurons towards those that are somatostatin positive. The increase in somatostatin-positive interneurons could also be prevented by pharmacological inhibition of the core RAS/MAPK signaling pathway. Overall, these findings present new insights into how different RAS...

... Cavanagh , M. E. and Parnavelas , J. G. ( 1988 ). Development of somatostatin immunoreactive neurons in the rat occipital cortex: a combined immunocytochemical-autoradiographic study . J. Comp. Neurol.   268 , 1 - 12 . 10.1002/cne.902680102 Chen , Y.-J. J. , Johnson , M...

...Jia Sheng Hu; Daniel Vogt; Susan Lindtner; Magnus Sandberg; Shanni N. Silberberg; John L. R. Rubenstein Distinct cortical interneuron (CIN) subtypes have unique circuit functions; dysfunction in specific subtypes is implicated in neuropsychiatric disorders. Somatostatin- and parvalbumin-expressing...

... somatostatin (SST) and those expressing parvalbumin (PV) – are specified in the MGE from Nkx2.1-expressing progenitors at higher or lower levels of sonic hedgehog (Shh) signaling, respectively. To further explore the role of Shh and other factors in cIN fate determination, we generated a reporter line...

...) of mice with either partial or complete loss of polySia synthesizing capacity by ablation of St8sia2 , St8sia4 , or both. Cells positive for parvalbumin and perineuronal nets as well as somatostatin-positive cells were reduced in the mPFC of all polyST-deficient lines, whereas calretinin-positive cells...

... interneurons - those that express parvalbumin (PV) or somatostatin(SST) - but direct targets of NKX2.1 remain to be established. We find that electroporation of Nkx2.1 cDNA into the ventral telencephalon of slice cultures from Nkx2.1 -/- mouse embryos, followed by transplantation into neonatal cortex to permit...

... progenitors. These results are corroborated by the examination of NestinCre: Shh Fl/Fl cortex at postnatal day 12, in which there is a dramatic reduction in cell profiles that express somatostatin or parvalbumin. By contrast, analyses of Dlx5/6Cre:Smoothened Fl/Fl mutant mice suggest that cell-autonomous...

... the neocortical subventricular zone and differentiate into the transient subpial granule neurons in the marginal zone and into a stable population of GABA-, parvalbumin- or somatostatin-expressing interneurons throughout the cortical plate. ‡Author for correspondence (e-mail: [email protected] ) 2...

... are different. * Author for correspondence 04 10 1995 © 1996 by Company of Biologists 1996 cell differentiation cell autonomous pituitary gland anterior dwarfism somatostatin thyrotropin prolactin The specification and expansion of diverse cell lineages from one or a few...

... somatostatin pancreatic polypeptide peptide YY amylin insulin promoter factor-1 (IPF-1) mesenchymal factor metaplasia streptozotocin The pancreas is a particularly important organ from the point of view of human medicine because it suffers from two important diseases: diabetes mellitus...

... of human fetal pancreas. * Author for correspondence 13 12 1992 © 1992 by Company of Biologists 1992 β -cell development EGF-R fetal glucagon insulin pancreas somatostatin TGF- α Transforming growth factor alpha (TGF- α ) is a mitogenic 50 amino acid polypeptide...

...Eleanor J. Mackie; Ulrich Trechsel; Christian Bruns Specific binding sites for the peptide hormone somatostatin have previously been demonstrated in long bones from neonatal rats. In the present study, the distribution of somatostatin receptors during embryonic bone formation has been investigated...

... to develop peptidergic phenotypes. Using immunocytochemical techniques, we show that substance P-, enkephalin- (leu-enkephalin, met-enkephalin), and somatostatin-like immunoreactivities are expressed in subpopulations of neurones grown in vitro , whereas VIP (vasoactive intestinal polypeptide...