1-20 of 30
Keywords: Smoothened
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199867.
Published: 4 October 2021
... degradation of the Hh transducer Smoothened (SMO). Deficiency of the MMM component MOSMO results in elevated SMO and increased Hh signaling, causing multiple birth defects. In utero exposure to a teratogen that directly inhibits SMO reduces the penetrance and expressivity of birth defects in Mosmo −/− embryos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev166892.
Published: 15 May 2019
... by patched on target cells, transduced across the cell membrane by smoothened, and transmitted to the nucleus by GLI proteins to influence gene-expression programs. * Authors for correspondence ( rrohatgi@stanford.edu , christian@strubi.ox.ac.uk ) Competing interests The authors declare...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev166850.
Published: 12 December 2018
...Cecile Giordano; Laurent Ruel; Candice Poux; Pascal Therond ABSTRACT Hedgehog (Hh) is a conserved morphogen that controls cell differentiation and tissue patterning in metazoans. In Drosophila , the Hh signal is transduced from the G protein-coupled receptor Smoothened (Smo) to the cytoplasmic Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3134–3144.
Published: 1 September 2017
... to adjacent cells of the anterior compartment. We monitored Hh:GFP after pulsed expression, and analyzed the movement and colocalization of Hh, Patched (Ptc) and Smoothened (Smo) proteins tagged with GFP or mCherry and expressed at physiological levels from bacterial artificial chromosome transgenes. Hh:GFP...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (7): 1317–1327.
Published: 1 April 2017
... and branching, but did not phenocopy transgenic expression of activated smoothened ( SmoM2 ). The epithelium showed no evidence of canonical hedgehog signaling, and hyperproliferation was not blocked by smoothened (SMO) inhibition, suggesting a non-canonical function of PTCH1. Consistent with this possibility...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (21): 4027–4037.
Published: 1 November 2016
... the neural crest and endoderm influences thymus and parathyroid cell fate establishment and subsequent organogenesis. Sonic hedgehog Smoothened Thymus Parathyroid Endoderm Neural crest Morphogenesis Mouse In mice, thymus and parathyroid organogenesis begins at E9.5, when the third...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 612–621.
Published: 1 February 2012
... Smoothened (Smo), a member of the G-protein-coupled receptor (GPCR) superfamily. The extracellular (EC) loops of canonical GPCRs harbor cysteine residues that engage in disulfide bonds, affecting active and inactive signaling states through regulating receptor conformation, dimerization and/or ligand binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 85–94.
Published: 1 January 2012
...Shuofei Cheng; Dominic Maier; David R. Hipfner G-protein-coupled receptor kinases (GRKs) play a conserved role in Hedgehog (Hh) signaling. In several systems, GRKs are required for efficient Hh target gene expression. Their principal target appears to be Smoothened (Smo), the intracellular signal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (23): 5121–5134.
Published: 1 December 2011
...Samantha England; Manuel F. Batista; John K. Mich; James K. Chen; Katharine E. Lewis In mouse, Hedgehog (Hh) signalling is required for most ventral spinal neurons to form. Here, we analyse the spinal cord phenotype of zebrafish maternal-zygotic smoothened ( MZsmo ) mutants that completely lack Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (8): 1263–1273.
Published: 15 April 2010
... of a patched homolog, At-ptc , that encodes a putative negative regulator of Hedgehog (Hh) signaling, prevented initiation of the symmetry-breaking cell migration. Knockdown of a smoothened homolog, At-smo , showed that Hh signaling inactivation also arrested the cells at the germ disc center, whereas moderate...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (24): 4111–4121.
Published: 15 December 2009
...) represses Smoothened (Smo) signaling by an unknown catalytic mechanism that correlates with reduced Smo levels on the basolateral membrane. Ptc contains a sterol-sensing domain and is similar to the Niemann-Pick type C-1 protein, suggesting that Ptc might regulate lipid trafficking to repress Smo. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3789–3799.
Published: 15 November 2008
... of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16 , 2743 -2748. Chen, J. N., Haffter, P., Odenthal, J., Vogelsang, E., Brand,M., van Eeden, F. J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M.,Heisenberg, C. P. et al. ( 1996 ). Mutations affecting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 4987–4998.
Published: 15 November 2005
... -3370. Traiffort, E., Charytoniuk, D. A., Faure, H. and Ruat, M. ( 1998 ). Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain. J. Neurochem. 70 , 1327 -1330. Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K.,Orban, P. C., Bock, R., Klein, R...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (20): 4461–4470.
Published: 15 October 2005
.... 2005 Myotome Danio rerio spadetail beamter fused somites sonic hedgehog sonic-you slow muscle omitted Smoothened unplugged you too after eight deadly seven Notch pathway mutants Although all vertebrates have a similar body plan, the early cell...
Journal Articles
Journal: Development
Development (2005) 132 (7): 1579–1590.
Published: 1 April 2005
..., whereas dlx3b and dlx4b are required to restrict pituitary placode size. In smoothened mutant embryos that cannot transduce Hedgehog signals,median pituitary precursors are mis-specified and form an ectopic lens. Moreover, overexpression of sonic hedgehog ( shh ) blocks lens formation, and derivatives...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (17): 3951–3963.
Published: 1 September 2003
... are mediated by the balance between repressor and activator forms of Cubitus interruptus, CiR and CiA. Hedgehog regulates this balance through its receptor, Patched, which acts through Smoothened and thence a regulatory complex that includes Fused, Costal, Suppressor of Fused and Cubitus interruptus...
Journal Articles
Journal: Development
Development (2002) 129 (23): 5323–5337.
Published: 1 December 2002
..., we have used the Cre-loxP system to remove Smoothened(Smo) activity in the dental epithelium. Smo, a seven-pass membrane protein is essential for the transduction of all Hh signals. Hence, removal of Smo activity from the dental epithelium should block Shh signaling within dental epithelial...
Journal Articles
Journal: Development
Development (2001) 128 (18): 3485–3495.
Published: 15 September 2001
.... ( 2001 ). Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development 128 , 2385 -2396. Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H. and Beachy, P. A. ( 1996 ). Cyclopia and defective axial patterning...