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Keywords: Smads
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Journal Articles
Journal: Development
Development (2018) 145 (14): dev164004.
Published: 26 July 2018
... Sox9, an important transcription factor of skeletogenesis. We further demonstrate that Erk5 directly phosphorylates and activates Smurf2 (a ubiquitin E3 ligase) at Thr 249 , which promotes the proteasomal degradation of Smad proteins and phosphorylates Smad1 at Ser 206 in the linker region known...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (16): 2803–2813.
Published: 15 August 2009
.... * Author for correspondence (e-mail: jim.smith@nimr.mrc.ac.uk ) 12 6 2009 © 2009. 2009 Xenopus TGF-β Smads Activin Nodal-related proteins Bimolecular fluorescence complementation (BiFC) Morphogen The mesoderm of the amphibian embryo forms from the equatorial region...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4209–4218.
Published: 1 December 2007
.... The phosphorylated Smad proteins form heteromeric complexes with Smad4 and translocate into the nucleus to activate the transcription, after the midblastula transition, of target genes such as Xbra and goosecoid( gsc ). In this paper we use bimolecular fluorescence complementation(BiFC) to study complex formation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (19): 4709–4723.
Published: 1 October 2004
... induction and heart-specific expression of CAR3. Adjacent YY1 and SMAD-binding sites within CAR3 constitute a minimal BMP response element, and interaction of SMAD1/4 with the N terminus of YY1 is required for BMP-mediated induction of CAR3. Our data suggest that BMP-mediated activation of this regulatory...
Includes: Supplementary data