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Keywords: Smad4
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Journal: Development
Development (2016) 143 (2): 339–347.
Published: 15 January 2016
... in Sp7 + cells specifically in postnatal mice increased trabecular bone mass. However, deletion of Smad4 by the same approaches had only a minor effect, indicating that Bmpr1a signaling suppresses trabecular bone formation through effectors beyond Smad4. Besides increasing osteoblast number...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (9): 1640–1650.
Published: 1 May 2012
... development. TGFβ family members play important roles in regulating myogenesis, but the functional significance of Smad-dependent TGFβ signaling in regulating tongue skeletal muscle development remains unclear. In this study, we have investigated Smad4-mediated TGFβ signaling in the development of occipital...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1977–1989.
Published: 15 May 2011
..., respectively. The functional significance of SMAD4, the common mediator of TGFβ/BMP signaling, in regulating the fate of CNC cells remains unclear. In this study, we investigated the mechanism of SMAD4 in regulating the fate of CNC-derived dental mesenchymal cells through tissue-specific inactivation of Smad4...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (11): 1919–1929.
Published: 1 June 2010
... conducted as previously described ( Wang et al., 2001 ). Each assay was conducted in triplicate at least two times in 12-well plates using the following expression plasmids: myocardin ( Wang et al., 2001 ), SRF ( Wang et al., 2001 ), Mef2c ( Wang et al., 2001 ), SMAD3 ( Feng et al., 2000 ), SMAD4 ( Feng et...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (18): 4593–4605.
Published: 15 September 2004
... is required for renewal of the mesenchyme progenitor population. Additionally, in vitro studies demonstrate inhibitory effects of BMPs and TGFβs on collecting duct branching and growth. Here,we explore the predicted models of TGFβ superfamily function by cell-specific inactivation of Smad4 , a key mediator...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (15): 3501–3512.
Published: 1 August 2004
...Gerald C. Chu; N. Ray Dunn; Dorian C. Anderson; Leif Oxburgh; Elizabeth J. Robertson Genetic and biochemical data have identified Smad4 as a key intracellular effector of the transforming growth factor β (TGFβ superfamily of secreted ligands. In mouse, Smad4 -null embryos do not gastrulate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1998) 125 (8): 1407–1420.
Published: 15 April 1998
... dorsal cell fates, demonstrating that Medea acts downstream of the thick veins receptor. We cloned Medea and found that it encodes a protein with striking sequence similarity to human SMAD4. Moreover, injection of human SMAD4 mRNA into embryos lacking all Medea activity conferred phenotypic rescue...