...Julie Gamart; Iros Barozzi; Frédéric Laurent; Robert Reinhardt; Laurène Ramos Martins; Thomas Oberholzer; Axel Visel; Rolf Zeller; Aimée Zuniga ABSTRACT SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its...

... protein (BMP) signal transduction in postnatal mice, with BMP signaling being restricted to basal VSNs and at the marginal zones of the VNO: the site of neurogenesis. Using different Smad4 conditional knockout mouse models, we disrupted canonical TGFβ/BMP signaling in either maturing basal VSNs (bVSNs...

... in Sp7 + cells specifically in postnatal mice increased trabecular bone mass. However, deletion of Smad4 by the same approaches had only a minor effect, indicating that Bmpr1a signaling suppresses trabecular bone formation through effectors beyond Smad4. Besides increasing osteoblast number...

... that regulates many steps of normal mammary gland (MG) development, including branching morphogenesis, functional differentiation and involution. Tif1γ has previously been reported to temporally and spatially control TGFβ signalling during early vertebrate development by exerting negative effects over SMAD4...

... development. TGFβ family members play important roles in regulating myogenesis, but the functional significance of Smad-dependent TGFβ signaling in regulating tongue skeletal muscle development remains unclear. In this study, we have investigated Smad4-mediated TGFβ signaling in the development of occipital...

..., respectively. The functional significance of SMAD4, the common mediator of TGFβ/BMP signaling, in regulating the fate of CNC cells remains unclear. In this study, we investigated the mechanism of SMAD4 in regulating the fate of CNC-derived dental mesenchymal cells through tissue-specific inactivation of Smad4...

... Heart Xenopus laevis Xenopus tropicalis SMAD1 SMAD4 T-box BMP Zebrafish Transgenesis A series of clinical studies has provided direct evidence of a role for T-box genes in heart development and human disease, as mutations in at least three T-box genes, TBX1, TBX5...

...., Li, C., Herrera, P. L. and Deng, C. X. ( 2002 ). Generation of Smad4/Dpc4 conditional knockout mice. Genesis 32 , 80 -81. Vessel formation in the developing embryo requires vasculogenesis and angiogenesis with successful recruitment of supporting cells such as smooth muscle cells (SMCs...

... is required for renewal of the mesenchyme progenitor population. Additionally, in vitro studies demonstrate inhibitory effects of BMPs and TGFβs on collecting duct branching and growth. Here,we explore the predicted models of TGFβ superfamily function by cell-specific inactivation of Smad4 , a key mediator...

...Gerald C. Chu; N. Ray Dunn; Dorian C. Anderson; Leif Oxburgh; Elizabeth J. Robertson Genetic and biochemical data have identified Smad4 as a key intracellular effector of the transforming growth factor β (TGFβ superfamily of secreted ligands. In mouse, Smad4 -null embryos do not gastrulate...

... dorsal cell fates, demonstrating that Medea acts downstream of the thick veins receptor. We cloned Medea and found that it encodes a protein with striking sequence similarity to human SMAD4. Moreover, injection of human SMAD4 mRNA into embryos lacking all Medea activity conferred phenotypic rescue...