... member 3 (SMAD3) to the promoter of the EGF-like growth factor amphiregulin ( Areg ). Notably, specific inhibition of HDAC4 promoted oocyte maturation independently of LH in vitro , and the developmental potential of these matured oocytes was comparable to those induced by LH in vitro . In conclusion...

... antagonist SB-431542. More importantly, Smad2 and Smad3 are differentially regulated post-translationally during the preparation phase of limb regeneration. Using specific antagonists for Smad2 and Smad3 we demonstrate that Smad2 is responsible for the action of TGF-β during regeneration, whereas Smad3...

... and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3...

...Lidia García-Campmany; Elisa Martí Here we show that Smad3, a transforming growth factor β(TGFβ)/activin signaling effector, is expressed in discrete progenitor domains along the dorsoventral axis of the developing chick spinal cord. Restriction of Smad3 expression to the dP6-p2 and p3 domains...