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Keywords: Smad2
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Journal Articles
Journal: Development
Development (2021) 148 (3): dev195495.
Published: 8 February 2021
...Émilie Lamarche; Hamood AlSudais; Rashida Rajgara; Dechen Fu; Saadeddine Omaiche; Nadine Wiper-Bergeron ABSTRACT SMAD2 is a transcription factor, the activity of which is regulated by members of the transforming growth factor β (TGFβ) superfamily. Although activation of SMAD2 and SMAD3 downstream...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3481–3490.
Published: 1 October 2016
... antagonist SB-431542. More importantly, Smad2 and Smad3 are differentially regulated post-translationally during the preparation phase of limb regeneration. Using specific antagonists for Smad2 and Smad3 we demonstrate that Smad2 is responsible for the action of TGF-β during regeneration, whereas Smad3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (3): 649–659.
Published: 1 February 2013
...Aidan J. Peterson; Michael B. O'Connor Imaginal disc development in Drosophila requires coordinated cellular proliferation and tissue patterning. In our studies of TGFβ superfamily signaling components, we found that a protein null mutation of Smad2 , the only Activin subfamily R-Smad in the fruit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (21): 3861–3872.
Published: 1 November 2007
... of BMP/Smad1 signaling does not induce neural markers efficiently in Xenopus ventral ectoderm, and show that suppression of both Smad1 and Smad2 signals is sufficient to induce neural markers. Manipulations that inhibit both Smad1 and Smad2 pathways, including a truncated type IIB activin receptor, Smad7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (22): 5613–5626.
Published: 15 November 2004
...Maki Daniels; Kazuya Shimizu; Aaron M. Zorn; Shin-ichi Ohnuma Mesoderm induction and patterning are primarily regulated by the concentration of locally expressed morphogens such as members of the TGFβsuperfamily. Smad2 functions as a transcription factor to regulate expression of mesodermal genes...
Journal Articles
Journal: Development
Development (2002) 129 (9): 2167–2180.
Published: 1 May 2002
... dissociated blastula cells of Xenopus exposed to activin for only 10 minutes, we have followed the phosphorylation of tagged Smad2, the principal activin transducer, from a cytoplasmic pool to the nucleus in real time. We show that a changing concentration of extracellular activin is rapidly and continuously...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4605–4613.
Published: 15 November 2001
... to develop but maxillary molars develop normally. In order to understand why maxillary molar tooth development can proceed in the absence of activin, we have explored the role of mediators of activin signalling in tooth development. Analysis of tooth development in activin receptor II and Smad2 mutants shows...