1-20 of 35
Keywords: Smad
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199984.
Published: 04 January 2022
... is that the neonatal kidney has the capacity to control interstitial cell proliferation when the target number has been reached. In this study, we define the consequences of inactivating the TGFβ/Smad response in the mouse interstitial cell lineage. We find that pathway inactivation through loss of Smad4 leads...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev184861.
Published: 26 May 2020
... Seuntjens ABSTRACT The transcription factor Zeb2 controls fate specification and subsequent differentiation and maturation of multiple cell types in various embryonic tissues. It binds many protein partners, including activated Smad proteins and the NuRD co-repressor complex. How Zeb2 subdomains support...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (21): 4015–4025.
Published: 01 November 2017
... is proposed to be crucial for nuclear movement, is regulated by Nodal signaling and nuclear envelope proteins. The non-Smad JNK signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad pathway, and this nuclear movement is associated with Smad signal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2896–2906.
Published: 15 August 2017
... the environment and proliferative germ cell accumulation. Neuronal DAF-7/TGFβ causes a DAF-1/TGFβR signaling cascade in the gonadal distal tip cell (DTC), the germline stem cell niche, where it negatively regulates a DAF-3 SMAD and DAF-5 Sno-Ski. LAG-2, a founding DSL ligand family member, is produced in the DTC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2121–2135.
Published: 15 June 2015
... has cell type-specific targets and functions: it acts with SMAD1 to promote mesoderm specification, while in the endoderm it interacts with SMAD2/3. SMAD T-BOX Embryonic stem cells Gastrulation Gene regulatory networks Human The three primary germ layers (ectoderm, mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1357–1367.
Published: 01 April 2015
... , Y. ( 2013 ). Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice . J. Bone Miner. Res.   28 , 1422 - 1433 . 10.1002/jbmr.1857 Kussie , P. H. , Gorina , S. , Marechal , V. , Elenbaas , B. , Moreau , J. , Levine , A. J...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (3): 533–543.
Published: 01 February 2015
.... Neurogenesis Glia Smad Id1 Mouse Several signaling pathways regulate the production and differentiation of glial cells in the central nervous system of vertebrates. For the astrocyte lineage, the best characterized of these signaling pathways is CNTF/LIF, acting through the gp130 receptor...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (23): 4537–4547.
Published: 01 December 2014
... 2014 © 2014. Published by The Company of Biologists Ltd 2014 Another enriched motif we identified is the Heb (bHLH family) motif ( supplementary material Fig. S11 ), also previously reported by Yoon et al. (2011) as being over-represented under Foxh1 and Smad peaks in human ESCs. The Heb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (12): 2414–2428.
Published: 15 June 2014
... In the embryonic CNS, development of myelin-forming oligodendrocytes is limited by bone morphogenetic proteins, which constitute one arm of the transforming growth factor-β (Tgfβ) family and signal canonically via Smads 1/5/8. Tgfβ ligands and Activins comprise the other arm and signal via Smads 2/3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (24): 4959–4969.
Published: 15 December 2013
... by The Company of Biologists Ltd 2013 Cell fate Eye Gsk3β Mitf Optic vesicle patterning Optic cup Retinal development Smad Vsx2 During vertebrate eye development, the optic neuroepithelium is specified into three domains: retinal pigment epithelium (RPE), neural retina (NR...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3343–3354.
Published: 15 September 2012
... autoregulatory pathway through the formation of an unusual BMP4-induced Smad complex containing Smad2 and Smad5. Quantitative expression analysis supports that ectopic Nodal expression in the Smad5 mutant amnion is induced by the Nodal autoregulatory loop and a slow positive-feedback loop. The latter involves...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 289–300.
Published: 15 January 2012
... prevents the ectopic expression of lateral ectoderm markers, independently of its role in neural specification. We then investigate the temporal participation of BMP/Smad signaling and suggest a later involvement in neural plate border development, likely due to widespread FGF/MAPK activity in the gastrula...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 755–765.
Published: 15 February 2011
..., a mediator of Hh signalling, and activated Smads (pSmads), mediators of bone morphogenic protein (BMP) signalling, in vivo. We found a strict negative correlation between nuclear accumulation of pSmad, and eng2a expression in myotomal cells and show that abrogation of pSmad accumulation results in activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2939–2949.
Published: 01 September 2010
... conserved among tetrapods and unexpectedly directed all the Emx2 expression in forebrain: caudal forebrain primordium at E8.5, dorsal telencephalon at E9.5-E10.5 and the cortical ventricular zone after E12.5. Otx, Tcf, Smad and two unknown transcription factor binding sites were essential to all...
Journal Articles
Journal: Development
Development (2009) 136 (21): 3557–3566.
Published: 01 November 2009
... University Hospital, Lund, Sweden 26 8 2009 © 2009. 2009 Kidney development Cap mesenchyme BMP SMAD JNK Development of the mammalian permanent kidney, or metanephros, is initiated at embryonic day (E) 10.5 in the mouse. Reciprocal interactions between the ureteric bud...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (7): 1093–1104.
Published: 01 April 2009
...Kelsey N. Retting; Buer Song; Byeong S. Yoon; Karen M. Lyons Bone morphogenetic protein (BMP) signaling is required for endochondral bone formation. However, whether or not the effects of BMPs are mediated via canonical Smad pathways or through noncanonical pathways is unknown. In this study we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4381–4393.
Published: 15 December 2007
... of e-cadherin , thereby perturbing cell movements during convergent extension, epiboly and node formation. Thus, although the role of Smad proteins in mediating Nodal signaling is well-documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3649–3664.
Published: 15 October 2007
... spatial expression and for autoregulation. The 5′regulatory region contains essential binding sites for homeodomain, bZIP, Oct,Tcf/Lef, Sox and Smad transcription factors, and a binding site for an unidentified spatial repressor possibly related to Myb. Soon after its initiation, nodal expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (11): 2061–2071.
Published: 01 June 2007
..., phosphorylation by Nemo blocks the nuclear accumulation of Mad by promoting export of Mad from the nucleus in a kinase-dependent manner. This is the first example of the inhibition of Drosophila BMP signaling by a MAPK and represents a novel mechanism of Smad inhibition through the phosphorylation of a conserved...
Journal Articles
Journal: Development
Development (2006) 133 (20): 4025–4034.
Published: 15 October 2006
... in the phosphorylation and nuclear translocation of Smads,downstream signal transducers that bind DNA. In Drosophila , the zinc finger protein Schnurri (Shn) plays a key role in signaling by the Bmp2/Bmp4 homolog Decapentaplegic (Dpp), by forming a Shn/Smad repression complex on defined promoter elements in the brinker...