...Olga G. Jaime; Jessica Arias; Shreya Pavani; April D. Pyle; Michael R. Hicks ABSTRACT The earliest skeletal muscle progenitor cells (SMPCs) derived from human pluripotent stem cells (hPSCs) are often identified by factors expressed by a diverse number of progenitors. An early transcriptional...

...Yudai Ono; Saundra Schlesinger; Kanako Fukunaga; Shinsei Yambe; Tempei Sato; Takako Sasaki; Chisa Shukunami; Hiroshi Asahara; Masafumi Inui ABSTRACT Movement of the vertebrate body is supported by the connection of muscle, tendon and bone. Each skeletal muscle in the vertebrate body has a unique...

... supplemented with 1 mM DTT. Human CapZ ( Rao et al., 2014 ), rabbit skeletal muscle actin ( Pardee et al., 1982 ) and rabbit skeletal muscle tropomyosin ( Smillie, 1982 ) were purified as described. Sequences of Drosophila Tmod isoforms and human TMOD3 were aligned using the program Clustal Omega...

... in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells . Nat. Commun. 2 , 499 . 10.1038/ncomms1508 Doyle , M. J. , Zhou , S. , Tanaka , K. K. , Pisconti , A. , Farina , N. H. , Sorrentino , B. P. and Olwin , B. B. ( 2011 ). Abcg2...

... micropeptide myomixer . Science   356 , 323 - 327 . 10.1126/science.aam9361 Biressi , S. , Molinaro , M. and Cossu , G. ( 2007a ). Cellular heterogeneity during vertebrate skeletal muscle development . Dev. Biol.   308 , 281 - 293 . 10.1016/j.ydbio.2007.06.006 Biressi , S...

...Megha Agarwal; Akashi Sharma; Pankaj Kumar; Amit Kumar; Anushree Bharadwaj; Masum Saini; Gabrielle Kardon; Sam J. Mathew ABSTRACT Myosin heavy chain-embryonic (MyHC-emb) is a skeletal muscle-specific contractile protein expressed during muscle development. Mutations in MYH3 , the gene encoding MyHC...

...Allison P. Kann; Robert S. Krauss ABSTRACT Skeletal muscle myofibers are large syncytial cells comprising hundreds of myonuclei, and in situ hybridization experiments have reported a range of transcript localization patterns within them. Although some transcripts are uniformly distributed...

.... , Mootoosamy , R. C. , Cheng , L. , Parkyn , G. , Lumsden , A. and Dietrich , S. ( 2003 ). Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors . Dev. Cell   5 , 379 - 390 . 10.1016/S1534-5807(03)00263-6 Anderson , C. , Williams , V. C. , Moyon...

... Skeletal muscle Transcription factors Epigenetics Cell signaling Differentiation National Institutes of Health 10.13039/100000002 1R01EY026202 Australian Research Council 10.13039/501100000923 FT110100573 Flinders Foundation Skeletal muscle owes its...

...-licence-1-1/ Summary: Analyses of conditional and genetic null mice reveal that HeyL and Hey1 function redundantly in MuSCs, and that HeyL requires Hes1 for effective DNA binding and biological activity. Notch Muscle stem cells Skeletal muscle Mouse Japan Society...

... skeletal muscle development, where it is a master regulator of the transition from embryonic to foetal myogenesis. Recently, Nfix was shown to be involved in adult muscle regeneration and in muscular dystrophies. Here, we have investigated the signalling that regulates Nfix expression, and show that JunB...

... Body skeletal muscles derive from the paraxial mesoderm, which forms in the posterior region of the embryo. Using microarrays, we characterize novel mouse presomitic mesoderm (PSM) markers and show that, unlike the abrupt transcriptome reorganization of the PSM, neural tube differentiation...

...Amir Mizbani; Edlira Luca; Elisabeth J. Rushing; Jan Krützfeldt MicroRNAs (miRNAs) are important regulators of skeletal muscle regeneration, but the underlying mechanisms are still incompletely understood. Here, comparative miRNA sequencing analysis of myogenic progenitor cells (MPs) and non...

... expression of JMJD3c followed by the forced expression of lineage-defining transcription factors enabled the hPSCs to activate tissue-specific genes directly. We have also shown that the introduction of JMJD3c facilitates the differentiation of hPSCs into functional hepatic cells and skeletal muscle cells...

... is implicated in myotube formation and, together with YAP/Taz/Tead1, is associated with reduced muscle fiber diameter of a subset of fast fibers. Axin2 Yap1 Wwtr1 Tead1 Skeletal muscle Muscle fibers Satellite cells The Wnt gene family encodes 19 secreted glycoproteins, which bind...

...: Satellite cell depletion prevents fiber hypertrophy in the plantaris and extensor digitorum longus muscles in mice, suggesting that satellite cells are obligatory for hypertrophic growth. Hypertrophy Plasticity Satellite cells Skeletal muscle Stem cells Mouse Norges Forskningsråd...

...Nicolas A. Dumont; Yu Xin Wang; Michael A. Rudnicki Muscle stem cells, termed satellite cells, are crucial for skeletal muscle growth and regeneration. In healthy adult muscle, satellite cells are quiescent but poised for activation. During muscle regeneration, activated satellite cells transiently...

.... ( 2007 ). Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis . J. Exp. Med.   204 , 1057 - 1069 . 10.1084/jem.20070075 Beauchamp , J. R. , Heslop , L. , Yu , D. S. W. , Tajbakhsh , S. , Kelly , R. G...

... in vivo tagging of the nuclear envelope with biotin and the subsequent affinity purification of the labeled nuclei. In this study we successfully purified nuclei of cardiac and skeletal muscle from Xenopus using this strategy. We went on to demonstrate the utility of this approach by coupling the INTACT...

... to be crucial, as Myod/Nfatc2 double-null mice die at birth, with a dramatic reduction of the major neonatal MHC isoform normally expressed at birth in skeletal muscles, such as limb and intercostal muscles, whereas its expression is unaffected in myofibers mutated for either factor alone. Using gel shift...